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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

Aging is an intricate process characterized by multiple hallmarks including stem cell exhaustion, genome instability, epigenome alteration, impaired proteostasis, and cellular senescence. Whereas each of these traits is detrimental at the cellular level, it remains unclear how they are interconnecte...

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Detalles Bibliográficos
Autores principales:	Guo, Yan, Chomiak, Alison.A., Hong, Ye, Lowe, Clara C., Kopsidas, Caroline A., Chan, Wen-Ching, Andrade, Jorge, Pan, Hongna, Zhou, Xiaoming, Monuki, Edwin S., Feng, Yuanyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213774/ https://www.ncbi.nlm.nih.gov/pubmed/35754718 http://dx.doi.org/10.1016/j.isci.2022.104519

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