Cargando…
The Suitability of Propolis as a Bioactive Component of Biomaterials
Propolis is a resinous product collected by bees from plant exudates to protect and maintain hive homeostasis. Propolis has been used therapeutically for centuries as folk medicine. Modern research investigating the diversity of the chemical composition and plant sources, biological activity, extrac...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213800/ https://www.ncbi.nlm.nih.gov/pubmed/35754488 http://dx.doi.org/10.3389/fphar.2022.930515 |
_version_ | 1784730918830735360 |
---|---|
author | Lesmana, Ronny Zulhendri, Felix Fearnley, James Irsyam, Ilham A. Rasyid, Renaldi P. H. N. Abidin, Trimurni Abdulah, Rizky Suwantika, Auliya Paradkar, Anant Budiman, Arief S. Pasang, Timotius |
author_facet | Lesmana, Ronny Zulhendri, Felix Fearnley, James Irsyam, Ilham A. Rasyid, Renaldi P. H. N. Abidin, Trimurni Abdulah, Rizky Suwantika, Auliya Paradkar, Anant Budiman, Arief S. Pasang, Timotius |
author_sort | Lesmana, Ronny |
collection | PubMed |
description | Propolis is a resinous product collected by bees from plant exudates to protect and maintain hive homeostasis. Propolis has been used therapeutically for centuries as folk medicine. Modern research investigating the diversity of the chemical composition and plant sources, biological activity, extraction processes, analytical methods, and therapeutic properties in clinical settings have been carried out extensively since the 1980s. Due to its antimicrobial, anti-inflammatory, and immuno-modulator properties, propolis appears to be a suitable bioactive component to be incorporated into biomaterials. This review article attempts to analyze the potential application of propolis as a biomaterial component from the available experimental evidence. The efficacy and compabitility of propolis depend upon factors, such as types of extracts and types of biomaterials. Generally, propolis appears to be compatible with hydroxyapatite/calcium phosphate-based biomaterials. Propolis enhances the antimicrobial properties of the resulting composite materials while improving the physicochemical properties. Furthermore, propolis is also compatible with wound/skin dressing biomaterials. Propolis improves the wound healing properties of the biomaterials with no negative effects on the physicochemical properties of the composite biomaterials. However, the effect of propolis on the glass-based biomaterials cannot be generalized. Depending on the concentration, types of extract, and geographical sources of the propolis, the effect on the glass biomaterials can either be an improvement or detrimental in terms of mechanical properties such as compressive strength and shear bond strength. In conclusion, two of the more consistent impacts of propolis across these different types of biomaterials are the enhancement of the antimicrobial and the immune-modulator/anti-inflammatory properties resulting from the combination of propolis and the biomaterials. |
format | Online Article Text |
id | pubmed-9213800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92138002022-06-23 The Suitability of Propolis as a Bioactive Component of Biomaterials Lesmana, Ronny Zulhendri, Felix Fearnley, James Irsyam, Ilham A. Rasyid, Renaldi P. H. N. Abidin, Trimurni Abdulah, Rizky Suwantika, Auliya Paradkar, Anant Budiman, Arief S. Pasang, Timotius Front Pharmacol Pharmacology Propolis is a resinous product collected by bees from plant exudates to protect and maintain hive homeostasis. Propolis has been used therapeutically for centuries as folk medicine. Modern research investigating the diversity of the chemical composition and plant sources, biological activity, extraction processes, analytical methods, and therapeutic properties in clinical settings have been carried out extensively since the 1980s. Due to its antimicrobial, anti-inflammatory, and immuno-modulator properties, propolis appears to be a suitable bioactive component to be incorporated into biomaterials. This review article attempts to analyze the potential application of propolis as a biomaterial component from the available experimental evidence. The efficacy and compabitility of propolis depend upon factors, such as types of extracts and types of biomaterials. Generally, propolis appears to be compatible with hydroxyapatite/calcium phosphate-based biomaterials. Propolis enhances the antimicrobial properties of the resulting composite materials while improving the physicochemical properties. Furthermore, propolis is also compatible with wound/skin dressing biomaterials. Propolis improves the wound healing properties of the biomaterials with no negative effects on the physicochemical properties of the composite biomaterials. However, the effect of propolis on the glass-based biomaterials cannot be generalized. Depending on the concentration, types of extract, and geographical sources of the propolis, the effect on the glass biomaterials can either be an improvement or detrimental in terms of mechanical properties such as compressive strength and shear bond strength. In conclusion, two of the more consistent impacts of propolis across these different types of biomaterials are the enhancement of the antimicrobial and the immune-modulator/anti-inflammatory properties resulting from the combination of propolis and the biomaterials. Frontiers Media S.A. 2022-06-08 /pmc/articles/PMC9213800/ /pubmed/35754488 http://dx.doi.org/10.3389/fphar.2022.930515 Text en Copyright © 2022 Lesmana, Zulhendri, Fearnley, Irsyam, Rasyid, Abidin, Abdulah, Suwantika, Paradkar, Budiman and Pasang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Lesmana, Ronny Zulhendri, Felix Fearnley, James Irsyam, Ilham A. Rasyid, Renaldi P. H. N. Abidin, Trimurni Abdulah, Rizky Suwantika, Auliya Paradkar, Anant Budiman, Arief S. Pasang, Timotius The Suitability of Propolis as a Bioactive Component of Biomaterials |
title | The Suitability of Propolis as a Bioactive Component of Biomaterials |
title_full | The Suitability of Propolis as a Bioactive Component of Biomaterials |
title_fullStr | The Suitability of Propolis as a Bioactive Component of Biomaterials |
title_full_unstemmed | The Suitability of Propolis as a Bioactive Component of Biomaterials |
title_short | The Suitability of Propolis as a Bioactive Component of Biomaterials |
title_sort | suitability of propolis as a bioactive component of biomaterials |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213800/ https://www.ncbi.nlm.nih.gov/pubmed/35754488 http://dx.doi.org/10.3389/fphar.2022.930515 |
work_keys_str_mv | AT lesmanaronny thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT zulhendrifelix thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT fearnleyjames thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT irsyamilhama thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT rasyidrenaldiphn thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT abidintrimurni thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT abdulahrizky thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT suwantikaauliya thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT paradkaranant thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT budimanariefs thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT pasangtimotius thesuitabilityofpropolisasabioactivecomponentofbiomaterials AT lesmanaronny suitabilityofpropolisasabioactivecomponentofbiomaterials AT zulhendrifelix suitabilityofpropolisasabioactivecomponentofbiomaterials AT fearnleyjames suitabilityofpropolisasabioactivecomponentofbiomaterials AT irsyamilhama suitabilityofpropolisasabioactivecomponentofbiomaterials AT rasyidrenaldiphn suitabilityofpropolisasabioactivecomponentofbiomaterials AT abidintrimurni suitabilityofpropolisasabioactivecomponentofbiomaterials AT abdulahrizky suitabilityofpropolisasabioactivecomponentofbiomaterials AT suwantikaauliya suitabilityofpropolisasabioactivecomponentofbiomaterials AT paradkaranant suitabilityofpropolisasabioactivecomponentofbiomaterials AT budimanariefs suitabilityofpropolisasabioactivecomponentofbiomaterials AT pasangtimotius suitabilityofpropolisasabioactivecomponentofbiomaterials |