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Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review

In recent years much focus has been on neuroimmune mechanisms of depression. As a consequence, many preclinical and clinical trials have been performed examining potential antidepressant effects of several anti-inflammatory drugs. The results of such trials have been varied. With the current manuscr...

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Autores principales: Bay-Richter, Cecilie, Wegener, Gregers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213814/
https://www.ncbi.nlm.nih.gov/pubmed/35754506
http://dx.doi.org/10.3389/fphar.2022.909981
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author Bay-Richter, Cecilie
Wegener, Gregers
author_facet Bay-Richter, Cecilie
Wegener, Gregers
author_sort Bay-Richter, Cecilie
collection PubMed
description In recent years much focus has been on neuroimmune mechanisms of depression. As a consequence, many preclinical and clinical trials have been performed examining potential antidepressant effects of several anti-inflammatory drugs. The results of such trials have been varied. With the current manuscript we wished to elucidate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on depressive-like behaviour in rodent models of depression by performing a systematic review of the available literature. We performed a systematic literature search in PubMed for rodent models of depression where NSAIDs were administered and a validated measure of depressive-like behaviour was applied. 858 studies were initially identified and screened using Covidence systematic review software. Of these 36 met the inclusion criteria and were included. The extracted articles contained data from both rat and mouse studies but primarily male animals were used. Several depression models were applied and 17 different NSAIDs were tested for antidepressant effects. Our results suggest that stress models are the best choice when examining antidepressant effects of NSAIDs. Furthermore, we found that rat models provide a more homogenous response than mouse models. Intriguingly, the use of female animals was only reported in three studies and these failed to find antidepressant effects of NSAIDs. This should be explored further. When comparing the different classes of NSAIDs, selective COX-2 inhibitors were shown to provide the most stable antidepressant effect compared to non-selective COX-inhibitors. Suggested mechanisms behind the antidepressant effects were attenuation of neuroinflammation, HPA-axis dysregulation and altered monoamine expression.
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spelling pubmed-92138142022-06-23 Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review Bay-Richter, Cecilie Wegener, Gregers Front Pharmacol Pharmacology In recent years much focus has been on neuroimmune mechanisms of depression. As a consequence, many preclinical and clinical trials have been performed examining potential antidepressant effects of several anti-inflammatory drugs. The results of such trials have been varied. With the current manuscript we wished to elucidate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on depressive-like behaviour in rodent models of depression by performing a systematic review of the available literature. We performed a systematic literature search in PubMed for rodent models of depression where NSAIDs were administered and a validated measure of depressive-like behaviour was applied. 858 studies were initially identified and screened using Covidence systematic review software. Of these 36 met the inclusion criteria and were included. The extracted articles contained data from both rat and mouse studies but primarily male animals were used. Several depression models were applied and 17 different NSAIDs were tested for antidepressant effects. Our results suggest that stress models are the best choice when examining antidepressant effects of NSAIDs. Furthermore, we found that rat models provide a more homogenous response than mouse models. Intriguingly, the use of female animals was only reported in three studies and these failed to find antidepressant effects of NSAIDs. This should be explored further. When comparing the different classes of NSAIDs, selective COX-2 inhibitors were shown to provide the most stable antidepressant effect compared to non-selective COX-inhibitors. Suggested mechanisms behind the antidepressant effects were attenuation of neuroinflammation, HPA-axis dysregulation and altered monoamine expression. Frontiers Media S.A. 2022-06-08 /pmc/articles/PMC9213814/ /pubmed/35754506 http://dx.doi.org/10.3389/fphar.2022.909981 Text en Copyright © 2022 Bay-Richter and Wegener. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Bay-Richter, Cecilie
Wegener, Gregers
Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
title Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
title_full Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
title_fullStr Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
title_full_unstemmed Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
title_short Antidepressant Effects of NSAIDs in Rodent Models of Depression—A Systematic Review
title_sort antidepressant effects of nsaids in rodent models of depression—a systematic review
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213814/
https://www.ncbi.nlm.nih.gov/pubmed/35754506
http://dx.doi.org/10.3389/fphar.2022.909981
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