The product of BMP-directed differentiation protocols for human primed pluripotent stem cells is placental trophoblast and not amnion

The observation that trophoblast (TB) can be generated from primed pluripotent stem cells (PSCs) by exposure to bone morphogenetic protein-4 (BMP4) when FGF2 and ACTIVIN signaling is minimized has recently been challenged with the suggestion that the procedure instead produces amnion. Here, by analy...

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Detalles Bibliográficos
Autores principales: Seetharam, Arun S., Vu, Ha T.H., Choi, Sehee, Khan, Teka, Sheridan, Megan A., Ezashi, Toshihiko, Roberts, R. Michael, Tuteja, Geetu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214062/
https://www.ncbi.nlm.nih.gov/pubmed/35594861
http://dx.doi.org/10.1016/j.stemcr.2022.04.014

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