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Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell

Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Over the past two decades, ex vivo HSC expa...

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Autores principales: Li, Jiaxing, Wang, Xiao, Ding, Jiayu, Zhu, Yasheng, Min, Wenjian, Kuang, Wenbing, Yuan, Kai, Sun, Chengliang, Yang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214065/
https://www.ncbi.nlm.nih.gov/pubmed/35755294
http://dx.doi.org/10.1016/j.apsb.2021.12.006
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author Li, Jiaxing
Wang, Xiao
Ding, Jiayu
Zhu, Yasheng
Min, Wenjian
Kuang, Wenbing
Yuan, Kai
Sun, Chengliang
Yang, Peng
author_facet Li, Jiaxing
Wang, Xiao
Ding, Jiayu
Zhu, Yasheng
Min, Wenjian
Kuang, Wenbing
Yuan, Kai
Sun, Chengliang
Yang, Peng
author_sort Li, Jiaxing
collection PubMed
description Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Over the past two decades, ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs. Till now, several small-molecule compounds have entered the phase I/II trials, showing safe and favorable pharmacological profiles. As HSC expansion has become a hot topic over recent years, many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue. Here, we will give an overview of HSC biology, discovery and medicinal chemistry development of small molecules, natural products targeting for HSC expansion, and their recent clinical progresses, as well as potential protein targets for HSC expansion.
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spelling pubmed-92140652022-06-23 Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell Li, Jiaxing Wang, Xiao Ding, Jiayu Zhu, Yasheng Min, Wenjian Kuang, Wenbing Yuan, Kai Sun, Chengliang Yang, Peng Acta Pharm Sin B Review Hematopoietic stem cell (HSC) transplantation is the only curative therapy for many diseases. HSCs from umbilical cord blood (UCB) source have many advantages over from bone marrow. However, limited HSC dose in a single CB unit restrict its widespread use. Over the past two decades, ex vivo HSC expansion with small molecules has been an effective approach for obtaining adequate HSCs. Till now, several small-molecule compounds have entered the phase I/II trials, showing safe and favorable pharmacological profiles. As HSC expansion has become a hot topic over recent years, many newly identified small molecules along with novel biological mechanisms for HSC expansion would help solve this challenging issue. Here, we will give an overview of HSC biology, discovery and medicinal chemistry development of small molecules, natural products targeting for HSC expansion, and their recent clinical progresses, as well as potential protein targets for HSC expansion. Elsevier 2022-06 2021-12-17 /pmc/articles/PMC9214065/ /pubmed/35755294 http://dx.doi.org/10.1016/j.apsb.2021.12.006 Text en © 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Li, Jiaxing
Wang, Xiao
Ding, Jiayu
Zhu, Yasheng
Min, Wenjian
Kuang, Wenbing
Yuan, Kai
Sun, Chengliang
Yang, Peng
Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
title Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
title_full Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
title_fullStr Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
title_full_unstemmed Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
title_short Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
title_sort development and clinical advancement of small molecules for ex vivo expansion of hematopoietic stem cell
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214065/
https://www.ncbi.nlm.nih.gov/pubmed/35755294
http://dx.doi.org/10.1016/j.apsb.2021.12.006
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