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JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found t...

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Detalles Bibliográficos
Autores principales:	Wang, Chong, Wang, Changyuan, Wu, Jingjing, Meng, Qiang, Jin, Huan, Sun, Huijun, Kaku, Taiichi, Chen, Jing, Huo, Xiaokui, Liu, Kexin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214236/ https://www.ncbi.nlm.nih.gov/pubmed/35754503 http://dx.doi.org/10.3389/fphar.2022.938813

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