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Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases

Nucleotide/nucleoside analogs (NAs) are important compounds used in antiviral drug development. To understand the action mode of NA drugs, we present an enzymology protocol to initially evaluate the intervention mechanism of the NTP forms of NAs on a coronaviral RNA-dependent RNA polymerase (RdRP)....

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Detalles Bibliográficos
Autores principales:	Liu, Qiaojie, Wu, Jiqin, Gong, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214276/ https://www.ncbi.nlm.nih.gov/pubmed/35761985 http://dx.doi.org/10.1016/j.xpro.2022.101468

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