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Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder caused by autoantibodies against platelet antigens resulting in platelet destruction and inhibition of platelet production. Occasionally, an inciting event such as a virus or vaccination can precipitate ITP. Several cases of ITP have be...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214295/ https://www.ncbi.nlm.nih.gov/pubmed/35725277 http://dx.doi.org/10.1136/bcr-2022-250153 |
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author | Koilpillai, Sarina Dominguez, Bianca Khan, Azeem Carlan, Steve |
author_facet | Koilpillai, Sarina Dominguez, Bianca Khan, Azeem Carlan, Steve |
author_sort | Koilpillai, Sarina |
collection | PubMed |
description | Immune thrombocytopenic purpura (ITP) is an autoimmune disorder caused by autoantibodies against platelet antigens resulting in platelet destruction and inhibition of platelet production. Occasionally, an inciting event such as a virus or vaccination can precipitate ITP. Several cases of ITP have been reported after the BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) SARS-CoV-2 (COVID-19) vaccines. All reported cases of post-vaccination ITP have resolved with medical therapy until this case. A man in his mid-20s developed bleeding from ITP 2 weeks after receiving the second dose of the Pfizer SARS-CoV-2 vaccine. All inpatient medical treatment attempts failed. On hospital day 40, a splenectomy was performed and he ultimately recovered and was discharged. Awareness of potential vaccination side effects is a fundamental element of refining and improving patient safety. This case illustrates that given the right circumstances, serious refractory ITP can develop in response to the second dose of the Pfizer SARS-CoV-2 vaccine. |
format | Online Article Text |
id | pubmed-9214295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-92142952022-07-07 Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine Koilpillai, Sarina Dominguez, Bianca Khan, Azeem Carlan, Steve BMJ Case Rep Case Reports: Adverse drug reactions and complications Immune thrombocytopenic purpura (ITP) is an autoimmune disorder caused by autoantibodies against platelet antigens resulting in platelet destruction and inhibition of platelet production. Occasionally, an inciting event such as a virus or vaccination can precipitate ITP. Several cases of ITP have been reported after the BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) SARS-CoV-2 (COVID-19) vaccines. All reported cases of post-vaccination ITP have resolved with medical therapy until this case. A man in his mid-20s developed bleeding from ITP 2 weeks after receiving the second dose of the Pfizer SARS-CoV-2 vaccine. All inpatient medical treatment attempts failed. On hospital day 40, a splenectomy was performed and he ultimately recovered and was discharged. Awareness of potential vaccination side effects is a fundamental element of refining and improving patient safety. This case illustrates that given the right circumstances, serious refractory ITP can develop in response to the second dose of the Pfizer SARS-CoV-2 vaccine. BMJ Publishing Group 2022-06-20 /pmc/articles/PMC9214295/ /pubmed/35725277 http://dx.doi.org/10.1136/bcr-2022-250153 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ. |
spellingShingle | Case Reports: Adverse drug reactions and complications Koilpillai, Sarina Dominguez, Bianca Khan, Azeem Carlan, Steve Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine |
title | Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine |
title_full | Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine |
title_fullStr | Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine |
title_full_unstemmed | Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine |
title_short | Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine |
title_sort | severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the covid-19 vaccine |
topic | Case Reports: Adverse drug reactions and complications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214295/ https://www.ncbi.nlm.nih.gov/pubmed/35725277 http://dx.doi.org/10.1136/bcr-2022-250153 |
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