NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

Nicotinamide phosphoribosyl transferase (NAMPT) is considered as a promising target for cancer therapy given its critical engagement in cancer metabolism and inflammation. However, therapeutic benefit of NAMPT enzymatic inhibitors appears very limited, likely due to the failure to intervene non-enzy...

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Detalles Bibliográficos
Autores principales: Wu, Ying, Pu, Congying, Fu, Yixian, Dong, Guoqiang, Huang, Min, Sheng, Chunquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214341/
https://www.ncbi.nlm.nih.gov/pubmed/35755293
http://dx.doi.org/10.1016/j.apsb.2021.12.017

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