Cargando…

Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD

INTRODUCTION: Recent studies on cognitive training in patients with Alzheimer’s disease (AD) showed positive long-term effects on cognition and daily living, suggesting remote computer-based programmes to increase training sessions while reducing patient’s travelling. The aim of this study is to exa...

Descripción completa

Detalles Bibliográficos
Autores principales: Dimachki, Samar, Tarpin-Bernard, Franck, Croisile, Bernard, Chainay, Hanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214369/
https://www.ncbi.nlm.nih.gov/pubmed/35725247
http://dx.doi.org/10.1136/bmjopen-2021-050993
_version_ 1784731000502222848
author Dimachki, Samar
Tarpin-Bernard, Franck
Croisile, Bernard
Chainay, Hanna
author_facet Dimachki, Samar
Tarpin-Bernard, Franck
Croisile, Bernard
Chainay, Hanna
author_sort Dimachki, Samar
collection PubMed
description INTRODUCTION: Recent studies on cognitive training in patients with Alzheimer’s disease (AD) showed positive long-term effects on cognition and daily living, suggesting remote computer-based programmes to increase training sessions while reducing patient’s travelling. The aim of this study is to examine short-term and long-term benefits of computer-based cognitive training at home in patients with mild to moderate AD, as a complement to the training in speech and language therapists’ (SLT) offices. The secondary purpose is to study training frequency required to obtain noticeable effects. METHODS AND ANALYSES: This is a national multicentre study, conducted in SLT offices. The patients follow training in one of three conditions: once a week in SLT office only (regular condition) and once a week in SLT office plus one or three times per week at home. The trainings’ content in SLT office and at home is identical. For all three groups near and far transfer will be compared with evaluate training frequency’s effect. Our primary outcome is executive and working memory scores in experimental tasks, and the secondary is neuropsychological tests and questionnaires’ scores. Linear models’ analyses are considered for all measures with a random intercept for patients and another for per practice. The fixed effects will be: three modality groups and time, repeated measures, (T0—pretraining, T1—post-training, T2—long-term follow-up) and the interaction pairs. ETHICS AND DISSEMINATION: The study got ethics approval of the national ethical committee CPP Sud Méditerranée III (No 2019-A00458-49) and of the National Commission for Information Technology and Liberties (No 919217). Informed consent is obtained from each participant. Results will be disseminated in oral communications or posters in international conferences and published in scientific journals. TRIAL REGISTRATION NUMBER: NCT04010175.
format Online
Article
Text
id pubmed-9214369
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-92143692022-07-07 Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD Dimachki, Samar Tarpin-Bernard, Franck Croisile, Bernard Chainay, Hanna BMJ Open Rehabilitation Medicine INTRODUCTION: Recent studies on cognitive training in patients with Alzheimer’s disease (AD) showed positive long-term effects on cognition and daily living, suggesting remote computer-based programmes to increase training sessions while reducing patient’s travelling. The aim of this study is to examine short-term and long-term benefits of computer-based cognitive training at home in patients with mild to moderate AD, as a complement to the training in speech and language therapists’ (SLT) offices. The secondary purpose is to study training frequency required to obtain noticeable effects. METHODS AND ANALYSES: This is a national multicentre study, conducted in SLT offices. The patients follow training in one of three conditions: once a week in SLT office only (regular condition) and once a week in SLT office plus one or three times per week at home. The trainings’ content in SLT office and at home is identical. For all three groups near and far transfer will be compared with evaluate training frequency’s effect. Our primary outcome is executive and working memory scores in experimental tasks, and the secondary is neuropsychological tests and questionnaires’ scores. Linear models’ analyses are considered for all measures with a random intercept for patients and another for per practice. The fixed effects will be: three modality groups and time, repeated measures, (T0—pretraining, T1—post-training, T2—long-term follow-up) and the interaction pairs. ETHICS AND DISSEMINATION: The study got ethics approval of the national ethical committee CPP Sud Méditerranée III (No 2019-A00458-49) and of the National Commission for Information Technology and Liberties (No 919217). Informed consent is obtained from each participant. Results will be disseminated in oral communications or posters in international conferences and published in scientific journals. TRIAL REGISTRATION NUMBER: NCT04010175. BMJ Publishing Group 2022-06-20 /pmc/articles/PMC9214369/ /pubmed/35725247 http://dx.doi.org/10.1136/bmjopen-2021-050993 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Rehabilitation Medicine
Dimachki, Samar
Tarpin-Bernard, Franck
Croisile, Bernard
Chainay, Hanna
Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD
title Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD
title_full Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD
title_fullStr Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD
title_full_unstemmed Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD
title_short Study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with AD
title_sort study design and protocol of a low to high intensity computer-based cognitive training at home in supplement to standard care in patients with ad
topic Rehabilitation Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214369/
https://www.ncbi.nlm.nih.gov/pubmed/35725247
http://dx.doi.org/10.1136/bmjopen-2021-050993
work_keys_str_mv AT dimachkisamar studydesignandprotocolofalowtohighintensitycomputerbasedcognitivetrainingathomeinsupplementtostandardcareinpatientswithad
AT tarpinbernardfranck studydesignandprotocolofalowtohighintensitycomputerbasedcognitivetrainingathomeinsupplementtostandardcareinpatientswithad
AT croisilebernard studydesignandprotocolofalowtohighintensitycomputerbasedcognitivetrainingathomeinsupplementtostandardcareinpatientswithad
AT chainayhanna studydesignandprotocolofalowtohighintensitycomputerbasedcognitivetrainingathomeinsupplementtostandardcareinpatientswithad