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Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer—a preclinical study

The human transferrin receptor (TFR) is overexpressed in most breast cancers, including preneoplastic ductal carcinoma in situ (DCIS). HB21(Fv)-PE40 is a single-chain immunotoxin (IT) engineered by fusing the variable region of a monoclonal antibody (HB21) against a TFR with a 40 kDa fragment of Pse...

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Detalles Bibliográficos
Autores principales:	Wang, Guannan, Kumar, Alok, Ding, Wanjun, Korangath, Preethi, Bera, Tapan, Wei, Junxia, Pai, Priya, Gabrielson, Kathleen, Pastan, Ira, Sukumar, Saraswati
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214490/ https://www.ncbi.nlm.nih.gov/pubmed/35675429 http://dx.doi.org/10.1073/pnas.2200200119

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