Rituximab abrogates aquaporin-4–specific germinal center activity in patients with neuromyelitis optica spectrum disorders

Neuromyelitis optica spectrum disorders (NMOSDs) are caused by immunoglobulin G (IgG) autoantibodies directed against the water channel aquaporin-4 (AQP4). In NMOSDs, discrete clinical relapses lead to disability and are robustly prevented by the anti-CD20 therapeutic rituximab; however, its mechani...

Descripción completa

Detalles Bibliográficos
Autores principales: Damato, Valentina, Theorell, Jakob, Al-Diwani, Adam, Kienzler, Anne-Kathrin, Makuch, Mateusz, Sun, Bo, Handel, Adam, Akdeniz, Deniz, Berretta, Antonio, Ramanathan, Sudarshini, Fower, Andrew, Whittam, Daniel, Gibbons, Emily, McGlashan, Nicholas, Green, Edward, Huda, Saif, Woodhall, Mark, Palace, Jacqueline, Sheerin, Fintan, Waters, Patrick, Leite, Maria I., Jacob, Anu, Irani, Sarosh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214492/
https://www.ncbi.nlm.nih.gov/pubmed/35666871
http://dx.doi.org/10.1073/pnas.2121804119

Ejemplares similares

Ejemplares similares