Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so far not been described. We now demonstrate the existence...

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Detalles Bibliográficos
Autores principales: Golec, Ewelina, Ekström, Alexander, Noga, Maciej, Omar-Hmeadi, Muhmmad, Lund, Per-Eric, Villoutreix, Bruno O., Krus, Ulrika, Wozniak, Katarzyna, Korsgren, Olle, Renström, Erik, Barg, Sebastian, King, Ben C., Blom, Anna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214515/
https://www.ncbi.nlm.nih.gov/pubmed/35666870
http://dx.doi.org/10.1073/pnas.2120083119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214515/
https://www.ncbi.nlm.nih.gov/pubmed/35666870
http://dx.doi.org/10.1073/pnas.2120083119

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