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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Human pancreatic islets highly express CD59, which is a glycosylphosphatidylinositol (GPI)-anchored cell-surface protein and is required for insulin secretion. How cell-surface CD59 could interact with intracellular exocytotic machinery has so far not been described. We now demonstrate the existence...

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Detalles Bibliográficos
Autores principales:	Golec, Ewelina, Ekström, Alexander, Noga, Maciej, Omar-Hmeadi, Muhmmad, Lund, Per-Eric, Villoutreix, Bruno O., Krus, Ulrika, Wozniak, Katarzyna, Korsgren, Olle, Renström, Erik, Barg, Sebastian, King, Ben C., Blom, Anna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214515/ https://www.ncbi.nlm.nih.gov/pubmed/35666870 http://dx.doi.org/10.1073/pnas.2120083119

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