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Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting

Thermodynamic preferences to form non-native conformations are crucial for understanding how nucleic acids fold and function. However, they are difficult to measure experimentally because this requires accurately determining the population of minor low-abundance (<10%) conformations in a sea of o...

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Detalles Bibliográficos
Autores principales: Rangadurai, Atul, Shi, Honglue, Xu, Yu, Liu, Bei, Abou Assi, Hala, Boom, John D., Zhou, Huiqing, Kimsey, Isaac J., Al-Hashimi, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214542/
https://www.ncbi.nlm.nih.gov/pubmed/35671421
http://dx.doi.org/10.1073/pnas.2112496119