Targeted drug release system based on pH-responsive PAA-POSS nanoparticles

An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to whic...

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Autores principales: Kim, Won Jung, Lee, Eu Hyun, Kwon, Yong-Jin, Ye, Sang-Kyu, Kim, Kyu oh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214607/
https://www.ncbi.nlm.nih.gov/pubmed/35800319
http://dx.doi.org/10.1039/d2ra01141g
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author Kim, Won Jung
Lee, Eu Hyun
Kwon, Yong-Jin
Ye, Sang-Kyu
Kim, Kyu oh
author_facet Kim, Won Jung
Lee, Eu Hyun
Kwon, Yong-Jin
Ye, Sang-Kyu
Kim, Kyu oh
author_sort Kim, Won Jung
collection PubMed
description An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 ± 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line.
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spelling pubmed-92146072022-07-06 Targeted drug release system based on pH-responsive PAA-POSS nanoparticles Kim, Won Jung Lee, Eu Hyun Kwon, Yong-Jin Ye, Sang-Kyu Kim, Kyu oh RSC Adv Chemistry An amphipathic PAA-POSS@DOX drug delivery system that responds sensitively to pH changes in the cancer microenvironment has been developed using a nanoparticle based on inorganic polyhedral oligomeric silsesquioxane (POSS). POSS was introduced to the carboxylic acid group of polyacrylic acid to which doxorubicin anticancer drug was loaded to prepare 480 ± 192 nm self-assembled nanoparticles. PAA-POSS had a high loading efficiency of over 75% and doxorubicin was quickly released to the target area responding sensitively to weakly acidic conditions. The possibility of employing PAA-POSS as a targeted drug delivery system has been confirmed by observing the death of cells of the MDA-MB-231 breast cancer line. The Royal Society of Chemistry 2022-06-22 /pmc/articles/PMC9214607/ /pubmed/35800319 http://dx.doi.org/10.1039/d2ra01141g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kim, Won Jung
Lee, Eu Hyun
Kwon, Yong-Jin
Ye, Sang-Kyu
Kim, Kyu oh
Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
title Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
title_full Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
title_fullStr Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
title_full_unstemmed Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
title_short Targeted drug release system based on pH-responsive PAA-POSS nanoparticles
title_sort targeted drug release system based on ph-responsive paa-poss nanoparticles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214607/
https://www.ncbi.nlm.nih.gov/pubmed/35800319
http://dx.doi.org/10.1039/d2ra01141g
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AT yesangkyu targeteddrugreleasesystembasedonphresponsivepaapossnanoparticles
AT kimkyuoh targeteddrugreleasesystembasedonphresponsivepaapossnanoparticles

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