B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignanc...

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Autores principales: Ojo, Ademola S., Asemota, Joseph, Ojukwu, Somtochukwu, Rajeh, Ahmad, Bot, Amina, Smith, Caitlyn J., Laziuk, Katsiaryna, Saleh, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214690/
https://www.ncbi.nlm.nih.gov/pubmed/35761945
http://dx.doi.org/10.3892/ol.2022.13365
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author Ojo, Ademola S.
Asemota, Joseph
Ojukwu, Somtochukwu
Rajeh, Ahmad
Bot, Amina
Smith, Caitlyn J.
Laziuk, Katsiaryna
Saleh, Mohammed
author_facet Ojo, Ademola S.
Asemota, Joseph
Ojukwu, Somtochukwu
Rajeh, Ahmad
Bot, Amina
Smith, Caitlyn J.
Laziuk, Katsiaryna
Saleh, Mohammed
author_sort Ojo, Ademola S.
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignancies and immunodeficiency syndromes are known triggers of HLH in adults. The present study reported the case of a middle-aged man with HLH triggered by B-cell lymphoma who was successfully treated with dexamethasone; etoposide, prednisone, vincristine, cyclophosphamide, hydroxy-doxorubicin and rituximab chemotherapy; and multiple intrathecal methotrexate with a good outcome.
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spelling pubmed-92146902022-06-26 B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report Ojo, Ademola S. Asemota, Joseph Ojukwu, Somtochukwu Rajeh, Ahmad Bot, Amina Smith, Caitlyn J. Laziuk, Katsiaryna Saleh, Mohammed Oncol Lett Articles Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignancies and immunodeficiency syndromes are known triggers of HLH in adults. The present study reported the case of a middle-aged man with HLH triggered by B-cell lymphoma who was successfully treated with dexamethasone; etoposide, prednisone, vincristine, cyclophosphamide, hydroxy-doxorubicin and rituximab chemotherapy; and multiple intrathecal methotrexate with a good outcome. D.A. Spandidos 2022-06-07 /pmc/articles/PMC9214690/ /pubmed/35761945 http://dx.doi.org/10.3892/ol.2022.13365 Text en Copyright: © Ojo et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Ojo, Ademola S.
Asemota, Joseph
Ojukwu, Somtochukwu
Rajeh, Ahmad
Bot, Amina
Smith, Caitlyn J.
Laziuk, Katsiaryna
Saleh, Mohammed
B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
title B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
title_full B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
title_fullStr B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
title_full_unstemmed B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
title_short B-cell lymphoma-associated hemophagocytic lymphohistiocytosis: A case report
title_sort b-cell lymphoma-associated hemophagocytic lymphohistiocytosis: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214690/
https://www.ncbi.nlm.nih.gov/pubmed/35761945
http://dx.doi.org/10.3892/ol.2022.13365
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