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Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214756/ https://www.ncbi.nlm.nih.gov/pubmed/35755418 http://dx.doi.org/10.3389/pore.2022.1610171 |
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author | Kertész, Gabriella Kállay, Krisztián Kassa, Csaba Zombori, Marianna Bodó, Imre Kiss, Csongor Szegedi, István Kriván, Gergely |
author_facet | Kertész, Gabriella Kállay, Krisztián Kassa, Csaba Zombori, Marianna Bodó, Imre Kiss, Csongor Szegedi, István Kriván, Gergely |
author_sort | Kertész, Gabriella |
collection | PubMed |
description | The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment, the preparation of the donor with severe hemophilia A required a special management with perioperative factor VIII substitution. Donation was successful without complications, and 18 months after transplantation, the patient and his donor are well without any long-term sequelae. To our knowledge, this is the first reported succesfull transplantation with hemophilic child serving as a bone marrow donor. The procedure did not mean a significant risk to donor health, so donors with hemophilia should not be excluded from donation. |
format | Online Article Text |
id | pubmed-9214756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92147562022-06-23 Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia Kertész, Gabriella Kállay, Krisztián Kassa, Csaba Zombori, Marianna Bodó, Imre Kiss, Csongor Szegedi, István Kriván, Gergely Pathol Oncol Res Pathology and Oncology Archive The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment, the preparation of the donor with severe hemophilia A required a special management with perioperative factor VIII substitution. Donation was successful without complications, and 18 months after transplantation, the patient and his donor are well without any long-term sequelae. To our knowledge, this is the first reported succesfull transplantation with hemophilic child serving as a bone marrow donor. The procedure did not mean a significant risk to donor health, so donors with hemophilia should not be excluded from donation. Frontiers Media S.A. 2022-06-08 /pmc/articles/PMC9214756/ /pubmed/35755418 http://dx.doi.org/10.3389/pore.2022.1610171 Text en Copyright © 2022 Kertész, Kállay, Kassa, Zombori, Bodó, Kiss, Szegedi and Kriván. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pathology and Oncology Archive Kertész, Gabriella Kállay, Krisztián Kassa, Csaba Zombori, Marianna Bodó, Imre Kiss, Csongor Szegedi, István Kriván, Gergely Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia |
title | Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia |
title_full | Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia |
title_fullStr | Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia |
title_full_unstemmed | Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia |
title_short | Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia |
title_sort | case report: a child with hemophilia a serves as donor for hematopoietic stem cell transplantation to cure his brother’s severe aplastic anemia |
topic | Pathology and Oncology Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214756/ https://www.ncbi.nlm.nih.gov/pubmed/35755418 http://dx.doi.org/10.3389/pore.2022.1610171 |
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