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Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia

The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment,...

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Autores principales: Kertész, Gabriella, Kállay, Krisztián, Kassa, Csaba, Zombori, Marianna, Bodó, Imre, Kiss, Csongor, Szegedi, István, Kriván, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214756/
https://www.ncbi.nlm.nih.gov/pubmed/35755418
http://dx.doi.org/10.3389/pore.2022.1610171
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author Kertész, Gabriella
Kállay, Krisztián
Kassa, Csaba
Zombori, Marianna
Bodó, Imre
Kiss, Csongor
Szegedi, István
Kriván, Gergely
author_facet Kertész, Gabriella
Kállay, Krisztián
Kassa, Csaba
Zombori, Marianna
Bodó, Imre
Kiss, Csongor
Szegedi, István
Kriván, Gergely
author_sort Kertész, Gabriella
collection PubMed
description The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment, the preparation of the donor with severe hemophilia A required a special management with perioperative factor VIII substitution. Donation was successful without complications, and 18 months after transplantation, the patient and his donor are well without any long-term sequelae. To our knowledge, this is the first reported succesfull transplantation with hemophilic child serving as a bone marrow donor. The procedure did not mean a significant risk to donor health, so donors with hemophilia should not be excluded from donation.
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spelling pubmed-92147562022-06-23 Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia Kertész, Gabriella Kállay, Krisztián Kassa, Csaba Zombori, Marianna Bodó, Imre Kiss, Csongor Szegedi, István Kriván, Gergely Pathol Oncol Res Pathology and Oncology Archive The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where in parallel with the patient’s conditioning treatment, the preparation of the donor with severe hemophilia A required a special management with perioperative factor VIII substitution. Donation was successful without complications, and 18 months after transplantation, the patient and his donor are well without any long-term sequelae. To our knowledge, this is the first reported succesfull transplantation with hemophilic child serving as a bone marrow donor. The procedure did not mean a significant risk to donor health, so donors with hemophilia should not be excluded from donation. Frontiers Media S.A. 2022-06-08 /pmc/articles/PMC9214756/ /pubmed/35755418 http://dx.doi.org/10.3389/pore.2022.1610171 Text en Copyright © 2022 Kertész, Kállay, Kassa, Zombori, Bodó, Kiss, Szegedi and Kriván. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Kertész, Gabriella
Kállay, Krisztián
Kassa, Csaba
Zombori, Marianna
Bodó, Imre
Kiss, Csongor
Szegedi, István
Kriván, Gergely
Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
title Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
title_full Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
title_fullStr Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
title_full_unstemmed Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
title_short Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Transplantation to Cure His Brother’s Severe Aplastic Anemia
title_sort case report: a child with hemophilia a serves as donor for hematopoietic stem cell transplantation to cure his brother’s severe aplastic anemia
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214756/
https://www.ncbi.nlm.nih.gov/pubmed/35755418
http://dx.doi.org/10.3389/pore.2022.1610171
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