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Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway

Peroxisome proliferator–activated receptor delta (PPARδ) agonists have been shown to exert beneficial effects in liver disease and reduce total bile acid levels. The mechanism(s) whereby PPARδ agonism reduces bile acid levels are, however, unknown, and therefore the aim of the present study was to i...

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Detalles Bibliográficos
Autores principales:	Kouno, Tetsuya, Liu, Xiao, Zhao, Huayi, Kisseleva, Tatiana, Cable, Edward E., Schnabl, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214809/ https://www.ncbi.nlm.nih.gov/pubmed/35605662 http://dx.doi.org/10.1016/j.jbc.2022.102056

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