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MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014
BACKGROUND: To explore the optimal Mediterranean diet (MedDiet) adherence score threshold for the association between inflammatory markers and cognitive performance among older adults. METHODS: In this cross-sectional study, we selected data of the elderly (≥ 60 years old) from the National Health a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215079/ https://www.ncbi.nlm.nih.gov/pubmed/35729501 http://dx.doi.org/10.1186/s12877-022-03140-1 |
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author | Liu, Shuting Chen, Xiaorong |
author_facet | Liu, Shuting Chen, Xiaorong |
author_sort | Liu, Shuting |
collection | PubMed |
description | BACKGROUND: To explore the optimal Mediterranean diet (MedDiet) adherence score threshold for the association between inflammatory markers and cognitive performance among older adults. METHODS: In this cross-sectional study, we selected data of the elderly (≥ 60 years old) from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 (n = 2830). Participants completed at least one cognitive measurement and two 24-h food recalls. By analyzing the relation between inflammatory markers and cognitive performance using the subdivided MedDiet adherence score, we got the optimal MedDiet adherence score threshold. Then the optimal threshold was used to divide participants into high and low MedDiet adherence groups and multivariate logistic regression models were developed to examine the association between inflammatory markers and cognitive performance in each group. Subgroup analysis was conducted based on gender, race, BMI, physical activity level, and chronic diseases. RESULTS: We chose 4 as the optimal MedDiet adherence score threshold and included these participants whose MedDiet adherence score was 4 or above into the high MedDiet adherence group, while the MedDiet adherence score of the low adherence group was less than 4. We found that the increased white blood cell (WBC) count (OR = 1.44, 95% CI: 1.09–1.90, P = 0.008), neutrophil count (OR = 1.30, 95% CI: 1.03–1.65, P = 0.023), and neutrophil-albumin ratio (NAR) (OR = 1.34, 95% CI: 1.06–1.70, P = 0.012) were all related to a higher risk of low cognitive performance in the low MedDiet adherence group. A higher PLR was linked to a reduced risk of low cognitive performance (OR = 0.86, 95% CI: 0.74–1.00, P = 0.036) in the high MedDiet adherence group. Significant differences were found in the associations of WBC count, neutrophil count and NAR with low cognitive performance between the low and high MedDiet adherence groups (all P < 0.001). The weakened negative association between inflammatory markers and cognitive performance in the high MedDiet adherence group also existed among male, non-Hispanic white, normal-weight, overweight, moderate work activity, moderate recreational activity, non-depression, hypertension, non-hypertension, non-diabetes, non-stroke, non-heart failure, non-coronary heart disease, or non-heart attack subpopulations of older adults. CONCLUSIONS: The optimal threshold for the MedDiet adherence score was 4, and the negative association between inflammation and cognitive performance could be weakened in older adults whose MedDiet adherence score was ≥ 4. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-03140-1. |
format | Online Article Text |
id | pubmed-9215079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92150792022-06-23 MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 Liu, Shuting Chen, Xiaorong BMC Geriatr Research BACKGROUND: To explore the optimal Mediterranean diet (MedDiet) adherence score threshold for the association between inflammatory markers and cognitive performance among older adults. METHODS: In this cross-sectional study, we selected data of the elderly (≥ 60 years old) from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 (n = 2830). Participants completed at least one cognitive measurement and two 24-h food recalls. By analyzing the relation between inflammatory markers and cognitive performance using the subdivided MedDiet adherence score, we got the optimal MedDiet adherence score threshold. Then the optimal threshold was used to divide participants into high and low MedDiet adherence groups and multivariate logistic regression models were developed to examine the association between inflammatory markers and cognitive performance in each group. Subgroup analysis was conducted based on gender, race, BMI, physical activity level, and chronic diseases. RESULTS: We chose 4 as the optimal MedDiet adherence score threshold and included these participants whose MedDiet adherence score was 4 or above into the high MedDiet adherence group, while the MedDiet adherence score of the low adherence group was less than 4. We found that the increased white blood cell (WBC) count (OR = 1.44, 95% CI: 1.09–1.90, P = 0.008), neutrophil count (OR = 1.30, 95% CI: 1.03–1.65, P = 0.023), and neutrophil-albumin ratio (NAR) (OR = 1.34, 95% CI: 1.06–1.70, P = 0.012) were all related to a higher risk of low cognitive performance in the low MedDiet adherence group. A higher PLR was linked to a reduced risk of low cognitive performance (OR = 0.86, 95% CI: 0.74–1.00, P = 0.036) in the high MedDiet adherence group. Significant differences were found in the associations of WBC count, neutrophil count and NAR with low cognitive performance between the low and high MedDiet adherence groups (all P < 0.001). The weakened negative association between inflammatory markers and cognitive performance in the high MedDiet adherence group also existed among male, non-Hispanic white, normal-weight, overweight, moderate work activity, moderate recreational activity, non-depression, hypertension, non-hypertension, non-diabetes, non-stroke, non-heart failure, non-coronary heart disease, or non-heart attack subpopulations of older adults. CONCLUSIONS: The optimal threshold for the MedDiet adherence score was 4, and the negative association between inflammation and cognitive performance could be weakened in older adults whose MedDiet adherence score was ≥ 4. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-022-03140-1. BioMed Central 2022-06-21 /pmc/articles/PMC9215079/ /pubmed/35729501 http://dx.doi.org/10.1186/s12877-022-03140-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Liu, Shuting Chen, Xiaorong MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 |
title | MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 |
title_full | MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 |
title_fullStr | MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 |
title_full_unstemmed | MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 |
title_short | MedDiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the NHANES 2011–2014 |
title_sort | meddiet adherence score for the association between inflammatory markers and cognitive performance in the elderly: a study of the nhanes 2011–2014 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215079/ https://www.ncbi.nlm.nih.gov/pubmed/35729501 http://dx.doi.org/10.1186/s12877-022-03140-1 |
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