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Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol

The outbreak of the coronavirus 2 disease 2019 (COVID-19) puts an enormous burden on healthcare systems worldwide. This may worsen outcomes in patients with severe chronic diseases such as cancer, autoimmune diseases, and immune deficiencies. In this critical situation, only a few available data exi...

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Autores principales: Silvestris, Nicola, Belleudi, Valeria, Addis, Antonio, Pimpinelli, Fulvia, Morrone, Aldo, Sciacchitano, Salvatore, Mancini, Rita, Garrisi, Vito Michele, Costantini, Massimo, Ciliberto, Gennaro, Frisardi, Vincenza, Piaggio, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215159/
https://www.ncbi.nlm.nih.gov/pubmed/35756683
http://dx.doi.org/10.3389/fonc.2022.828660
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author Silvestris, Nicola
Belleudi, Valeria
Addis, Antonio
Pimpinelli, Fulvia
Morrone, Aldo
Sciacchitano, Salvatore
Mancini, Rita
Garrisi, Vito Michele
Costantini, Massimo
Ciliberto, Gennaro
Frisardi, Vincenza
Piaggio, Giulia
author_facet Silvestris, Nicola
Belleudi, Valeria
Addis, Antonio
Pimpinelli, Fulvia
Morrone, Aldo
Sciacchitano, Salvatore
Mancini, Rita
Garrisi, Vito Michele
Costantini, Massimo
Ciliberto, Gennaro
Frisardi, Vincenza
Piaggio, Giulia
author_sort Silvestris, Nicola
collection PubMed
description The outbreak of the coronavirus 2 disease 2019 (COVID-19) puts an enormous burden on healthcare systems worldwide. This may worsen outcomes in patients with severe chronic diseases such as cancer, autoimmune diseases, and immune deficiencies. In this critical situation, only a few available data exist, which do not allow us to provide practical guides for the treatment of oncological or immunocompromised patients. Therefore, a further step forward is needed, addressing the specific needs and demands of frail patients in the pandemic era. Here we aim to present a protocol of a study approved by an ethical committee named “CO.M.E.TA”. CO.M.E.TA protocol is a network project involving six Italian institutions and its goals are: i) to measure and compare the impact of the pandemic on the access of cancer and immunocompromised patients to therapies in three Italian regions; ii) to assess how reorganizational measures put in place in these different institutions have impacted specific metrics of performance; iii) to establish a COVID-19 Biobank of biological samples from SARS-CoV-2 infected patients to be used to study immunological alterations in patients with immune frailty.
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spelling pubmed-92151592022-06-23 Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol Silvestris, Nicola Belleudi, Valeria Addis, Antonio Pimpinelli, Fulvia Morrone, Aldo Sciacchitano, Salvatore Mancini, Rita Garrisi, Vito Michele Costantini, Massimo Ciliberto, Gennaro Frisardi, Vincenza Piaggio, Giulia Front Oncol Oncology The outbreak of the coronavirus 2 disease 2019 (COVID-19) puts an enormous burden on healthcare systems worldwide. This may worsen outcomes in patients with severe chronic diseases such as cancer, autoimmune diseases, and immune deficiencies. In this critical situation, only a few available data exist, which do not allow us to provide practical guides for the treatment of oncological or immunocompromised patients. Therefore, a further step forward is needed, addressing the specific needs and demands of frail patients in the pandemic era. Here we aim to present a protocol of a study approved by an ethical committee named “CO.M.E.TA”. CO.M.E.TA protocol is a network project involving six Italian institutions and its goals are: i) to measure and compare the impact of the pandemic on the access of cancer and immunocompromised patients to therapies in three Italian regions; ii) to assess how reorganizational measures put in place in these different institutions have impacted specific metrics of performance; iii) to establish a COVID-19 Biobank of biological samples from SARS-CoV-2 infected patients to be used to study immunological alterations in patients with immune frailty. Frontiers Media S.A. 2022-06-02 /pmc/articles/PMC9215159/ /pubmed/35756683 http://dx.doi.org/10.3389/fonc.2022.828660 Text en Copyright © 2022 Silvestris, Belleudi, Addis, Pimpinelli, Morrone, Sciacchitano, Mancini, Garrisi, Costantini, Ciliberto, Frisardi and Piaggio https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Silvestris, Nicola
Belleudi, Valeria
Addis, Antonio
Pimpinelli, Fulvia
Morrone, Aldo
Sciacchitano, Salvatore
Mancini, Rita
Garrisi, Vito Michele
Costantini, Massimo
Ciliberto, Gennaro
Frisardi, Vincenza
Piaggio, Giulia
Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
title Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
title_full Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
title_fullStr Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
title_full_unstemmed Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
title_short Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
title_sort development of approaches and metrics to measure the impact and improve the clinical outcomes of patients with frailty in the era of covid-19. the cometa italian protocol
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215159/
https://www.ncbi.nlm.nih.gov/pubmed/35756683
http://dx.doi.org/10.3389/fonc.2022.828660
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