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The NKT cell TCR repertoire can accommodate structural modifications to the lipid and orientation of the terminal carbohydrate of iGb3

Isoglobotrihexosylceramide (iGb3) is a known NKT cell agonist, however the specific interactions required to trigger NKT cell TCR activation in response to this mammalian glycolipid are not fully understood. Here we report the synthesis of 1,3-β-Gal-LacCer (βG-iGb3) that displays a β-linked terminal...

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Detalles Bibliográficos
Autores principales:	Cameron, Garth, Cheng, Janice M. H., Godfrey, Dale I., Timmer, Mattie S. M., Stocker, Bridget L., Dangerfield, Emma M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215340/ https://www.ncbi.nlm.nih.gov/pubmed/35799937 http://dx.doi.org/10.1039/d2ra02373c

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