A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination

Clozapine is an atypical antipsychotic used for treatment‐resistant schizophrenia and is known to cause serious side effects, such as leukopenia and neutropenia. We encountered the case of a 44‐year‐old female patient with a good response to clozapine, who experienced inflammatory reaction and cytop...

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Autores principales: Imai, Tomoyuki, Ochiai, Sho, Ishimaru, Takehiro, Daitoku, Hayato, Miyagawa, Yusuke, Fukuhara, Ryuji, Boku, Shuken, Takebayashi, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216366/
https://www.ncbi.nlm.nih.gov/pubmed/35166466
http://dx.doi.org/10.1002/npr2.12238
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author Imai, Tomoyuki
Ochiai, Sho
Ishimaru, Takehiro
Daitoku, Hayato
Miyagawa, Yusuke
Fukuhara, Ryuji
Boku, Shuken
Takebayashi, Minoru
author_facet Imai, Tomoyuki
Ochiai, Sho
Ishimaru, Takehiro
Daitoku, Hayato
Miyagawa, Yusuke
Fukuhara, Ryuji
Boku, Shuken
Takebayashi, Minoru
author_sort Imai, Tomoyuki
collection PubMed
description Clozapine is an atypical antipsychotic used for treatment‐resistant schizophrenia and is known to cause serious side effects, such as leukopenia and neutropenia. We encountered the case of a 44‐year‐old female patient with a good response to clozapine, who experienced inflammatory reaction and cytopenia after coronavirus disease 2019 (COVID‐19) vaccination. Soon after clozapine discontinuation, the inflammatory reaction resolved, and cell counts recovered. There are only a few reports on the interaction between clozapine and COVID‐19 vaccine. Our findings suggest that caution is required when a patient who is receiving clozapine scheduled for COVID‐19 vaccination, owing to the possibility of cytopenia. Moreover, blood tests and the measurement of clozapine concentration should be performed before and after the inoculation to ensure patient safety.
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spelling pubmed-92163662022-06-29 A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination Imai, Tomoyuki Ochiai, Sho Ishimaru, Takehiro Daitoku, Hayato Miyagawa, Yusuke Fukuhara, Ryuji Boku, Shuken Takebayashi, Minoru Neuropsychopharmacol Rep Case Reports Clozapine is an atypical antipsychotic used for treatment‐resistant schizophrenia and is known to cause serious side effects, such as leukopenia and neutropenia. We encountered the case of a 44‐year‐old female patient with a good response to clozapine, who experienced inflammatory reaction and cytopenia after coronavirus disease 2019 (COVID‐19) vaccination. Soon after clozapine discontinuation, the inflammatory reaction resolved, and cell counts recovered. There are only a few reports on the interaction between clozapine and COVID‐19 vaccine. Our findings suggest that caution is required when a patient who is receiving clozapine scheduled for COVID‐19 vaccination, owing to the possibility of cytopenia. Moreover, blood tests and the measurement of clozapine concentration should be performed before and after the inoculation to ensure patient safety. John Wiley and Sons Inc. 2022-02-15 /pmc/articles/PMC9216366/ /pubmed/35166466 http://dx.doi.org/10.1002/npr2.12238 Text en © 2022 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Imai, Tomoyuki
Ochiai, Sho
Ishimaru, Takehiro
Daitoku, Hayato
Miyagawa, Yusuke
Fukuhara, Ryuji
Boku, Shuken
Takebayashi, Minoru
A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination
title A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination
title_full A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination
title_fullStr A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination
title_full_unstemmed A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination
title_short A case report: Clozapine‐induced leukopenia and neutropenia after mRNA COVID‐19 vaccination
title_sort case report: clozapine‐induced leukopenia and neutropenia after mrna covid‐19 vaccination
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216366/
https://www.ncbi.nlm.nih.gov/pubmed/35166466
http://dx.doi.org/10.1002/npr2.12238
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