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Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
There is a growing interest in applying double-dose repetitive transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for stress-related psychiatric disorders. Such stimulation protocols may shorten the treatment duration and may result in faster symptom improvement. Currently, theta-burst s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216409/ https://www.ncbi.nlm.nih.gov/pubmed/35755208 http://dx.doi.org/10.1016/j.cpnec.2022.100127 |
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author | De Witte, Sara De Smet, Stefanie Pulopulos, Matias M. Baeken, Chris |
author_facet | De Witte, Sara De Smet, Stefanie Pulopulos, Matias M. Baeken, Chris |
author_sort | De Witte, Sara |
collection | PubMed |
description | There is a growing interest in applying double-dose repetitive transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for stress-related psychiatric disorders. Such stimulation protocols may shorten the treatment duration and may result in faster symptom improvement. Currently, theta-burst stimulation (TBS) protocols have gained attention because of their significantly reduced treatment duration, compared to conventional rTMS. However, the effect of one or twice daily rTMS sessions remains unclear in relation to stress. Using a two-period cross-over design, we examined the impact of double-dosed intermittent (TBS) over the left dorsolateral prefrontal cortex on stress responses (salivary cortisol) in thirty-eight healthy participants after being stressed by a validated psychosocial stress task: the Trier Social Stress Test. After the first active iTBS session, as contrasted to sham, no differential effects on salivary output were observed. However, after the second active session, there was a significantly smaller decrease of salivary cortisol concentrations in the active iTBS condition compared to sham. Our results suggest that double-dosed iTBS after being stressed might differently affect stress recovery compared to a single session of iTBS. |
format | Online Article Text |
id | pubmed-9216409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92164092022-06-24 Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers De Witte, Sara De Smet, Stefanie Pulopulos, Matias M. Baeken, Chris Compr Psychoneuroendocrinol Article There is a growing interest in applying double-dose repetitive transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for stress-related psychiatric disorders. Such stimulation protocols may shorten the treatment duration and may result in faster symptom improvement. Currently, theta-burst stimulation (TBS) protocols have gained attention because of their significantly reduced treatment duration, compared to conventional rTMS. However, the effect of one or twice daily rTMS sessions remains unclear in relation to stress. Using a two-period cross-over design, we examined the impact of double-dosed intermittent (TBS) over the left dorsolateral prefrontal cortex on stress responses (salivary cortisol) in thirty-eight healthy participants after being stressed by a validated psychosocial stress task: the Trier Social Stress Test. After the first active iTBS session, as contrasted to sham, no differential effects on salivary output were observed. However, after the second active session, there was a significantly smaller decrease of salivary cortisol concentrations in the active iTBS condition compared to sham. Our results suggest that double-dosed iTBS after being stressed might differently affect stress recovery compared to a single session of iTBS. Elsevier 2022-02-25 /pmc/articles/PMC9216409/ /pubmed/35755208 http://dx.doi.org/10.1016/j.cpnec.2022.100127 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article De Witte, Sara De Smet, Stefanie Pulopulos, Matias M. Baeken, Chris Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers |
title | Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers |
title_full | Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers |
title_fullStr | Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers |
title_full_unstemmed | Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers |
title_short | Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers |
title_sort | double the dose, double the impact? effects of itbs on salivary cortisol in stressed healthy volunteers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216409/ https://www.ncbi.nlm.nih.gov/pubmed/35755208 http://dx.doi.org/10.1016/j.cpnec.2022.100127 |
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