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Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers

There is a growing interest in applying double-dose repetitive transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for stress-related psychiatric disorders. Such stimulation protocols may shorten the treatment duration and may result in faster symptom improvement. Currently, theta-burst s...

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Detalles Bibliográficos
Autores principales: De Witte, Sara, De Smet, Stefanie, Pulopulos, Matias M., Baeken, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216409/
https://www.ncbi.nlm.nih.gov/pubmed/35755208
http://dx.doi.org/10.1016/j.cpnec.2022.100127
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author De Witte, Sara
De Smet, Stefanie
Pulopulos, Matias M.
Baeken, Chris
author_facet De Witte, Sara
De Smet, Stefanie
Pulopulos, Matias M.
Baeken, Chris
author_sort De Witte, Sara
collection PubMed
description There is a growing interest in applying double-dose repetitive transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for stress-related psychiatric disorders. Such stimulation protocols may shorten the treatment duration and may result in faster symptom improvement. Currently, theta-burst stimulation (TBS) protocols have gained attention because of their significantly reduced treatment duration, compared to conventional rTMS. However, the effect of one or twice daily rTMS sessions remains unclear in relation to stress. Using a two-period cross-over design, we examined the impact of double-dosed intermittent (TBS) over the left dorsolateral prefrontal cortex on stress responses (salivary cortisol) in thirty-eight healthy participants after being stressed by a validated psychosocial stress task: the Trier Social Stress Test. After the first active iTBS session, as contrasted to sham, no differential effects on salivary output were observed. However, after the second active session, there was a significantly smaller decrease of salivary cortisol concentrations in the active iTBS condition compared to sham. Our results suggest that double-dosed iTBS after being stressed might differently affect stress recovery compared to a single session of iTBS.
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spelling pubmed-92164092022-06-24 Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers De Witte, Sara De Smet, Stefanie Pulopulos, Matias M. Baeken, Chris Compr Psychoneuroendocrinol Article There is a growing interest in applying double-dose repetitive transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for stress-related psychiatric disorders. Such stimulation protocols may shorten the treatment duration and may result in faster symptom improvement. Currently, theta-burst stimulation (TBS) protocols have gained attention because of their significantly reduced treatment duration, compared to conventional rTMS. However, the effect of one or twice daily rTMS sessions remains unclear in relation to stress. Using a two-period cross-over design, we examined the impact of double-dosed intermittent (TBS) over the left dorsolateral prefrontal cortex on stress responses (salivary cortisol) in thirty-eight healthy participants after being stressed by a validated psychosocial stress task: the Trier Social Stress Test. After the first active iTBS session, as contrasted to sham, no differential effects on salivary output were observed. However, after the second active session, there was a significantly smaller decrease of salivary cortisol concentrations in the active iTBS condition compared to sham. Our results suggest that double-dosed iTBS after being stressed might differently affect stress recovery compared to a single session of iTBS. Elsevier 2022-02-25 /pmc/articles/PMC9216409/ /pubmed/35755208 http://dx.doi.org/10.1016/j.cpnec.2022.100127 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
De Witte, Sara
De Smet, Stefanie
Pulopulos, Matias M.
Baeken, Chris
Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
title Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
title_full Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
title_fullStr Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
title_full_unstemmed Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
title_short Double the dose, double the impact? Effects of iTBS on salivary cortisol in stressed healthy volunteers
title_sort double the dose, double the impact? effects of itbs on salivary cortisol in stressed healthy volunteers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216409/
https://www.ncbi.nlm.nih.gov/pubmed/35755208
http://dx.doi.org/10.1016/j.cpnec.2022.100127
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