Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

Although immunotherapy has revolutionized cancer treatment, many immunogenic tumors remain refractory to treatment. This can be largely attributed to an immunologically “cold” tumor microenvironment characterized by an accumulation of immunosuppressive myeloid cells and exclusion of activated T cell...

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Detalles Bibliográficos
Autores principales: Poh, Ashleigh R., Love, Christopher G., Chisanga, David, Steer, James H., Baloyan, David, Chopin, Michaël, Nutt, Stephen, Rautela, Jai, Huntington, Nicholas D., Etemadi, Nima, O’Brien, Megan, O’Keefe, Ryan, Ellies, Lesley G., Macri, Christophe, Mintern, Justine D., Whitehead, Lachlan, Gangadhara, Gangadhara, Boon, Louis, Chand, Ashwini L., Lowell, Clifford A., Shi, Wei, Pixley, Fiona J., Ernst, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216510/
https://www.ncbi.nlm.nih.gov/pubmed/35731867
http://dx.doi.org/10.1126/sciadv.abl7882

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