SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex

Munc18-1 forms a template to organize assembly of the neuronal SNARE complex that triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where its amino-terminal region interacts with the SNARE motif, and later binding to synaptobrevin. However, the mechanism of SNAR...

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Detalles Bibliográficos
Autores principales: Stepien, Karolina P., Xu, Junjie, Zhang, Xuewu, Bai, Xiao-Chen, Rizo, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216511/
https://www.ncbi.nlm.nih.gov/pubmed/35731863
http://dx.doi.org/10.1126/sciadv.abo5272

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