Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge

Interleukin-11 (IL-11) is a profibrotic cytokine essential for the differentiation of fibroblasts into collagen-secreting, actin alpha 2, smooth muscle–positive (ACTA2(+)) myofibroblasts, driving processes underlying the pathogenesis of idiopathic pulmonary fibrosis (IPF). Here, we developed an inha...

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Detalles Bibliográficos
Autores principales: Bai, Xin, Zhao, Guolin, Chen, Qijing, Li, Zhongyu, Gao, Mingzhu, Ho, William, Xu, Xiaoyang, Zhang, Xue-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216512/
https://www.ncbi.nlm.nih.gov/pubmed/35731866
http://dx.doi.org/10.1126/sciadv.abn7162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216512/
https://www.ncbi.nlm.nih.gov/pubmed/35731866
http://dx.doi.org/10.1126/sciadv.abn7162

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