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Flexible bioelectronic device fabricated by conductive polymer–based living material

Living materials are worked as an inside collaborative system that could naturally respond to changing environmental conditions. The regulation of bioelectronic processes in living materials could be effective for collecting biological signals and detecting biomarkers. Here, we constructed a living...

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Detalles Bibliográficos
Autores principales: Wang, Zenghao, Bai, Haotian, Yu, Wen, Gao, Zhiqiang, Chen, Weijian, Yang, Zhiwen, Zhu, Chuanwei, Huang, Yiming, Lv, Fengting, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216517/
https://www.ncbi.nlm.nih.gov/pubmed/35731871
http://dx.doi.org/10.1126/sciadv.abo1458
Descripción
Sumario:Living materials are worked as an inside collaborative system that could naturally respond to changing environmental conditions. The regulation of bioelectronic processes in living materials could be effective for collecting biological signals and detecting biomarkers. Here, we constructed a living material with conjugated polymers poly[3-(3′-N,N,N-triethylamino-1′-propyloxy)-4-methyl-2,5-thiophene chloride] (PMNT) and Shewanella oneidensis MR-1 biofilm. In addition, the living material was integrated as a flexible bioelectronic device for lactate detection in physiological fluids (sweat, urine, and plasma). Owing to the electroconductivity of conjugated polymers, PMNT could optimize the bioelectronic process in the living material. The collected electrical signal could be wirelessly transferred to a portable smartphone for reading and analyzing. Because lactate is also a biomarker for cancer treatment, the flexible bioelectronic device was further used to detect and count the cancer cells. The proof of the bioelectronic device using conductive polymer–based living material exhibits promising applications in the next-generation personal health monitoring systems.