Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma

Hürthle cell carcinomas (HCCs) display two exceptional genotypes: near-homoplasmic mutation of mitochondrial DNA (mtDNA) and genome-wide loss of heterozygosity (gLOH). To understand the phenotypic consequences of these genetic alterations, we analyzed genomic, metabolomic, and immunophenotypic data...

Descripción completa

Detalles Bibliográficos
Autores principales: Ganly, Ian, Liu, Eric Minwei, Kuo, Fengshen, Makarov, Vladimir, Dong, Yiyu, Park, Jinsung, Gong, Yongxing, Gorelick, Alexander N., Knauf, Jeffrey A, Benedetti, Elisa, Tait-Mulder, Jacqueline, Morris, Luc G.T., Fagin, James A., Intlekofer, Andrew M, Krumsiek, Jan, Gammage, Payam A., Ghossein, Ronald, Xu, Bin, Chan, Timothy A., Reznik, Ed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216518/
https://www.ncbi.nlm.nih.gov/pubmed/35731870
http://dx.doi.org/10.1126/sciadv.abn9699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216518/
https://www.ncbi.nlm.nih.gov/pubmed/35731870
http://dx.doi.org/10.1126/sciadv.abn9699

Ejemplares similares