Liver cancer heterogeneity modeled by in situ genome editing of hepatocytes

Mechanistic study and precision treatment of primary liver cancer (PLC) are hindered by marked heterogeneity, which is challenging to recapitulate in any given liver cancer mouse model. Here, we report the generation of 25 mouse models of PLC by in situ genome editing of hepatocytes recapitulating 2...

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Detalles Bibliográficos
Autores principales: Tang, Mei, Zhao, Yang, Zhao, Jianhui, Wei, Shumei, Liu, Mingwei, Zheng, Nairen, Geng, Didi, Han, Shixun, Zhang, Yuchao, Zhong, Guoxuan, Li, Shuaifeng, Zhang, Xiuming, Wang, Chenliang, Yan, Huan, Cao, Xiaolei, Li, Li, Bai, Xueli, Ji, Junfang, Feng, Xin-Hua, Qin, Jun, Liang, Tingbo, Zhao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216519/
https://www.ncbi.nlm.nih.gov/pubmed/35731873
http://dx.doi.org/10.1126/sciadv.abn5683

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