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Function and evolution of the prototypic CD28ζ and 4-1BBζ chimeric antigen receptors
T cells engineered to express chimeric antigen receptors (CARs) specific for CD19 have yielded remarkable clinical outcomes in patients with refractory B-cell malignancies. The first CARs to be approved by the US Food and Drug Administration and the European Medicines Agency are CD19 CARs that compr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216534/ https://www.ncbi.nlm.nih.gov/pubmed/35757562 http://dx.doi.org/10.1016/j.iotech.2020.09.001 |