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Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
Positive social experiences may induce oxytocin release. However, previous studies of moral elevation have generally utilized cross-sectional and simple modeling approaches to establish the relationship between oxytocin and emotional stimuli. Utilizing a cohort of 30 non-lactating women (aged 23.6 ±...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216598/ https://www.ncbi.nlm.nih.gov/pubmed/35755919 http://dx.doi.org/10.1016/j.cpnec.2021.100105 |
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author | Parkitny, Luke Carter, C. Sue Peckins, Melissa K. Hon, Deirdre Ann Saturn, Sarina Nazarloo, H.P. Hurlbut, William Knutson, Brian Crane, Steven Harris, Xiola Younger, Jarred |
author_facet | Parkitny, Luke Carter, C. Sue Peckins, Melissa K. Hon, Deirdre Ann Saturn, Sarina Nazarloo, H.P. Hurlbut, William Knutson, Brian Crane, Steven Harris, Xiola Younger, Jarred |
author_sort | Parkitny, Luke |
collection | PubMed |
description | Positive social experiences may induce oxytocin release. However, previous studies of moral elevation have generally utilized cross-sectional and simple modeling approaches to establish the relationship between oxytocin and emotional stimuli. Utilizing a cohort of 30 non-lactating women (aged 23.6 ± 5.7 years), we tested whether exposure to a video identified as capable of eliciting moral elevation could change plasma oxytocin levels. Uniquely, we utilized a high-frequency longitudinal sampling approach and multilevel growth curve modeling with landmark registration to test physiological responses. The moral elevation stimulus, versus a control video, elicited significantly greater reports of being “touched/inspired” and “happy/joyful”. However, the measured plasma oxytocin response was found to be markedly heterogeneous. While the moral elevation stimulus elicited increased plasma oxytocin as expected, this increase was only modestly larger than that seen following the control video. This increase was also only present in some individuals. We found no relationship between plasma oxytocin and self-report responses to the stimulus. From these data, we argue that future studies of the relationship between oxytocin and emotion need to anticipate heterogeneous responses and thus incorporate comprehensive individual psychological data; these should include evidence-based variables known to be associated with oxytocin such as a history of trauma, and the individual’s psychological and emotional state at the time of testing. Given the complexity of physiological oxytocin release, such studies also need to incorporate frequent biological sampling to properly examine the dynamics of hormonal release and response. |
format | Online Article Text |
id | pubmed-9216598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92165982022-06-24 Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation Parkitny, Luke Carter, C. Sue Peckins, Melissa K. Hon, Deirdre Ann Saturn, Sarina Nazarloo, H.P. Hurlbut, William Knutson, Brian Crane, Steven Harris, Xiola Younger, Jarred Compr Psychoneuroendocrinol Special Issue on Love and Fear Positive social experiences may induce oxytocin release. However, previous studies of moral elevation have generally utilized cross-sectional and simple modeling approaches to establish the relationship between oxytocin and emotional stimuli. Utilizing a cohort of 30 non-lactating women (aged 23.6 ± 5.7 years), we tested whether exposure to a video identified as capable of eliciting moral elevation could change plasma oxytocin levels. Uniquely, we utilized a high-frequency longitudinal sampling approach and multilevel growth curve modeling with landmark registration to test physiological responses. The moral elevation stimulus, versus a control video, elicited significantly greater reports of being “touched/inspired” and “happy/joyful”. However, the measured plasma oxytocin response was found to be markedly heterogeneous. While the moral elevation stimulus elicited increased plasma oxytocin as expected, this increase was only modestly larger than that seen following the control video. This increase was also only present in some individuals. We found no relationship between plasma oxytocin and self-report responses to the stimulus. From these data, we argue that future studies of the relationship between oxytocin and emotion need to anticipate heterogeneous responses and thus incorporate comprehensive individual psychological data; these should include evidence-based variables known to be associated with oxytocin such as a history of trauma, and the individual’s psychological and emotional state at the time of testing. Given the complexity of physiological oxytocin release, such studies also need to incorporate frequent biological sampling to properly examine the dynamics of hormonal release and response. Elsevier 2021-12-22 /pmc/articles/PMC9216598/ /pubmed/35755919 http://dx.doi.org/10.1016/j.cpnec.2021.100105 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Special Issue on Love and Fear Parkitny, Luke Carter, C. Sue Peckins, Melissa K. Hon, Deirdre Ann Saturn, Sarina Nazarloo, H.P. Hurlbut, William Knutson, Brian Crane, Steven Harris, Xiola Younger, Jarred Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
title | Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
title_full | Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
title_fullStr | Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
title_full_unstemmed | Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
title_short | Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
title_sort | longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation |
topic | Special Issue on Love and Fear |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216598/ https://www.ncbi.nlm.nih.gov/pubmed/35755919 http://dx.doi.org/10.1016/j.cpnec.2021.100105 |
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