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Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation

Positive social experiences may induce oxytocin release. However, previous studies of moral elevation have generally utilized cross-sectional and simple modeling approaches to establish the relationship between oxytocin and emotional stimuli. Utilizing a cohort of 30 non-lactating women (aged 23.6 ±...

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Autores principales: Parkitny, Luke, Carter, C. Sue, Peckins, Melissa K., Hon, Deirdre Ann, Saturn, Sarina, Nazarloo, H.P., Hurlbut, William, Knutson, Brian, Crane, Steven, Harris, Xiola, Younger, Jarred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216598/
https://www.ncbi.nlm.nih.gov/pubmed/35755919
http://dx.doi.org/10.1016/j.cpnec.2021.100105
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author Parkitny, Luke
Carter, C. Sue
Peckins, Melissa K.
Hon, Deirdre Ann
Saturn, Sarina
Nazarloo, H.P.
Hurlbut, William
Knutson, Brian
Crane, Steven
Harris, Xiola
Younger, Jarred
author_facet Parkitny, Luke
Carter, C. Sue
Peckins, Melissa K.
Hon, Deirdre Ann
Saturn, Sarina
Nazarloo, H.P.
Hurlbut, William
Knutson, Brian
Crane, Steven
Harris, Xiola
Younger, Jarred
author_sort Parkitny, Luke
collection PubMed
description Positive social experiences may induce oxytocin release. However, previous studies of moral elevation have generally utilized cross-sectional and simple modeling approaches to establish the relationship between oxytocin and emotional stimuli. Utilizing a cohort of 30 non-lactating women (aged 23.6 ± 5.7 years), we tested whether exposure to a video identified as capable of eliciting moral elevation could change plasma oxytocin levels. Uniquely, we utilized a high-frequency longitudinal sampling approach and multilevel growth curve modeling with landmark registration to test physiological responses. The moral elevation stimulus, versus a control video, elicited significantly greater reports of being “touched/inspired” and “happy/joyful”. However, the measured plasma oxytocin response was found to be markedly heterogeneous. While the moral elevation stimulus elicited increased plasma oxytocin as expected, this increase was only modestly larger than that seen following the control video. This increase was also only present in some individuals. We found no relationship between plasma oxytocin and self-report responses to the stimulus. From these data, we argue that future studies of the relationship between oxytocin and emotion need to anticipate heterogeneous responses and thus incorporate comprehensive individual psychological data; these should include evidence-based variables known to be associated with oxytocin such as a history of trauma, and the individual’s psychological and emotional state at the time of testing. Given the complexity of physiological oxytocin release, such studies also need to incorporate frequent biological sampling to properly examine the dynamics of hormonal release and response.
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spelling pubmed-92165982022-06-24 Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation Parkitny, Luke Carter, C. Sue Peckins, Melissa K. Hon, Deirdre Ann Saturn, Sarina Nazarloo, H.P. Hurlbut, William Knutson, Brian Crane, Steven Harris, Xiola Younger, Jarred Compr Psychoneuroendocrinol Special Issue on Love and Fear Positive social experiences may induce oxytocin release. However, previous studies of moral elevation have generally utilized cross-sectional and simple modeling approaches to establish the relationship between oxytocin and emotional stimuli. Utilizing a cohort of 30 non-lactating women (aged 23.6 ± 5.7 years), we tested whether exposure to a video identified as capable of eliciting moral elevation could change plasma oxytocin levels. Uniquely, we utilized a high-frequency longitudinal sampling approach and multilevel growth curve modeling with landmark registration to test physiological responses. The moral elevation stimulus, versus a control video, elicited significantly greater reports of being “touched/inspired” and “happy/joyful”. However, the measured plasma oxytocin response was found to be markedly heterogeneous. While the moral elevation stimulus elicited increased plasma oxytocin as expected, this increase was only modestly larger than that seen following the control video. This increase was also only present in some individuals. We found no relationship between plasma oxytocin and self-report responses to the stimulus. From these data, we argue that future studies of the relationship between oxytocin and emotion need to anticipate heterogeneous responses and thus incorporate comprehensive individual psychological data; these should include evidence-based variables known to be associated with oxytocin such as a history of trauma, and the individual’s psychological and emotional state at the time of testing. Given the complexity of physiological oxytocin release, such studies also need to incorporate frequent biological sampling to properly examine the dynamics of hormonal release and response. Elsevier 2021-12-22 /pmc/articles/PMC9216598/ /pubmed/35755919 http://dx.doi.org/10.1016/j.cpnec.2021.100105 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special Issue on Love and Fear
Parkitny, Luke
Carter, C. Sue
Peckins, Melissa K.
Hon, Deirdre Ann
Saturn, Sarina
Nazarloo, H.P.
Hurlbut, William
Knutson, Brian
Crane, Steven
Harris, Xiola
Younger, Jarred
Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
title Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
title_full Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
title_fullStr Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
title_full_unstemmed Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
title_short Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
title_sort longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation
topic Special Issue on Love and Fear
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216598/
https://www.ncbi.nlm.nih.gov/pubmed/35755919
http://dx.doi.org/10.1016/j.cpnec.2021.100105
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