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Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh

OBJECTIVE: Human papillomavirus (HPV) comprises around 120 genotypically related viruses, classified into low- and high-risk HPVs, which are capable of replicating inside the keratinocytes of skin or mucous membranes. Studies suggest that infections with HPV-16 or HPV-18 have a higher rate of develo...

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Autores principales: Sharmin, Shahana, Sabikunnahar, Bristy, Aditya, Arpita, Khan, Md Abdullah-Al-Kamran, Nessa, Ashrafun, Ahsan, Chowdhury Rafiqul, Yasmin, Mahmuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216681/
https://www.ncbi.nlm.nih.gov/pubmed/35757826
http://dx.doi.org/10.1016/j.ijregi.2021.10.005
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author Sharmin, Shahana
Sabikunnahar, Bristy
Aditya, Arpita
Khan, Md Abdullah-Al-Kamran
Nessa, Ashrafun
Ahsan, Chowdhury Rafiqul
Yasmin, Mahmuda
author_facet Sharmin, Shahana
Sabikunnahar, Bristy
Aditya, Arpita
Khan, Md Abdullah-Al-Kamran
Nessa, Ashrafun
Ahsan, Chowdhury Rafiqul
Yasmin, Mahmuda
author_sort Sharmin, Shahana
collection PubMed
description OBJECTIVE: Human papillomavirus (HPV) comprises around 120 genotypically related viruses, classified into low- and high-risk HPVs, which are capable of replicating inside the keratinocytes of skin or mucous membranes. Studies suggest that infections with HPV-16 or HPV-18 have a higher rate of developing cancer. The aim of our study was to detect HPV early, and to estimate the genotype-specific prevalence of HPV in apparently healthy and asymptomatic females in Bangladesh. METHOD: After cervical swab specimen collection, a VIA test was performed to identify any type of abnormality in the cervix. A multiplex PCR amplification of HPV DNA, using L1 consensus primer systems, was performed with type-specific primers, followed by sequencing to detect HPV genotypes. RESULT: Of the 417 females, 121 were found to be HPV positive. The most prevalent high-risk HPV genotypes were found to be HPV-16 and HPV-18. Different patient demographic parameters, such as age, socioeconomic status, education, and history of first intercourse, were also studied to establish correlations with HPV infection. CONCLUSION: Our results might provide some insights into factors that influence the development of cervical cancer. They might also help in guiding better patient management, increased public health awareness, further testing, and the implementation of existing vaccines.
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spelling pubmed-92166812022-06-24 Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh Sharmin, Shahana Sabikunnahar, Bristy Aditya, Arpita Khan, Md Abdullah-Al-Kamran Nessa, Ashrafun Ahsan, Chowdhury Rafiqul Yasmin, Mahmuda IJID Reg Original Report OBJECTIVE: Human papillomavirus (HPV) comprises around 120 genotypically related viruses, classified into low- and high-risk HPVs, which are capable of replicating inside the keratinocytes of skin or mucous membranes. Studies suggest that infections with HPV-16 or HPV-18 have a higher rate of developing cancer. The aim of our study was to detect HPV early, and to estimate the genotype-specific prevalence of HPV in apparently healthy and asymptomatic females in Bangladesh. METHOD: After cervical swab specimen collection, a VIA test was performed to identify any type of abnormality in the cervix. A multiplex PCR amplification of HPV DNA, using L1 consensus primer systems, was performed with type-specific primers, followed by sequencing to detect HPV genotypes. RESULT: Of the 417 females, 121 were found to be HPV positive. The most prevalent high-risk HPV genotypes were found to be HPV-16 and HPV-18. Different patient demographic parameters, such as age, socioeconomic status, education, and history of first intercourse, were also studied to establish correlations with HPV infection. CONCLUSION: Our results might provide some insights into factors that influence the development of cervical cancer. They might also help in guiding better patient management, increased public health awareness, further testing, and the implementation of existing vaccines. Elsevier 2021-10-21 /pmc/articles/PMC9216681/ /pubmed/35757826 http://dx.doi.org/10.1016/j.ijregi.2021.10.005 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Report
Sharmin, Shahana
Sabikunnahar, Bristy
Aditya, Arpita
Khan, Md Abdullah-Al-Kamran
Nessa, Ashrafun
Ahsan, Chowdhury Rafiqul
Yasmin, Mahmuda
Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh
title Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh
title_full Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh
title_fullStr Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh
title_full_unstemmed Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh
title_short Genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in Bangladesh
title_sort genotypic distribution and prevalence of human papillomavirus infection in an apparently healthy female population in bangladesh
topic Original Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216681/
https://www.ncbi.nlm.nih.gov/pubmed/35757826
http://dx.doi.org/10.1016/j.ijregi.2021.10.005
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