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Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses

Previously, we showed that coagulation factors directly cleave SARS-CoV-2 spike and promote viral entry (Kastenhuber et al., 2022). Here, we show that substitutions in the S1/S2 cleavage site observed in SARS-CoV-2 variants of concern (VOCs) exhibit divergent interactions with host proteases, includ...

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Detalles Bibliográficos
Autores principales:	Kastenhuber, Edward R., Johnson, Jared L., Yaron, Tomer M., Mercadante, Marisa, Cantley, Lewis C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216717/ https://www.ncbi.nlm.nih.gov/pubmed/35734085 http://dx.doi.org/10.1101/2022.06.16.496428

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