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Successful Preservation of Native BCR::ABL1 in Chronic Myeloid Leukemia Primary Leukocytes Reveals a Reduced Kinase Activity

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by the acquisition of t(9;22) generating the fusion tyrosine kinase BCR::ABL1. However, despite the crucial role of this protein in the dysregulation of numerous signal transduction pathways, a direct measure of BCR::ABL1 kinase a...

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Detalles Bibliográficos
Autores principales:	Boni, Christian, Bonifacio, Massimiliano, Vezzalini, Marzia, Scaffidi, Luigi, Tomasello, Luisa, Parker, Laurie L., Boscarino, Diego, Paladin, Dino, Krampera, Mauro, Sorio, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216732/ https://www.ncbi.nlm.nih.gov/pubmed/35756686 http://dx.doi.org/10.3389/fonc.2022.904510

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