A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM

Teriflunomide is a pyrimidine synthesis inhibitor used in the treatment of multiple sclerosis that has in rare instances been associated with liver toxicity, though there are few documented cases. Here, we report a case of probable teriflunomide-induced liver injury as assessed for causality using t...

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Autor principal: Wurzburger, Riana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217622/
https://www.ncbi.nlm.nih.gov/pubmed/35756947
http://dx.doi.org/10.1155/2022/6331923
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author Wurzburger, Riana
author_facet Wurzburger, Riana
author_sort Wurzburger, Riana
collection PubMed
description Teriflunomide is a pyrimidine synthesis inhibitor used in the treatment of multiple sclerosis that has in rare instances been associated with liver toxicity, though there are few documented cases. Here, we report a case of probable teriflunomide-induced liver injury as assessed for causality using the updated RUCAM. The liver injury occurred approximately nine months after teriflunomide initiation and improved with discontinuation of the drug and treatment with cholestyramine.
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spelling pubmed-92176222022-06-23 A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM Wurzburger, Riana Case Reports Hepatol Case Report Teriflunomide is a pyrimidine synthesis inhibitor used in the treatment of multiple sclerosis that has in rare instances been associated with liver toxicity, though there are few documented cases. Here, we report a case of probable teriflunomide-induced liver injury as assessed for causality using the updated RUCAM. The liver injury occurred approximately nine months after teriflunomide initiation and improved with discontinuation of the drug and treatment with cholestyramine. Hindawi 2022-06-15 /pmc/articles/PMC9217622/ /pubmed/35756947 http://dx.doi.org/10.1155/2022/6331923 Text en Copyright © 2022 Riana Wurzburger. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wurzburger, Riana
A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM
title A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM
title_full A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM
title_fullStr A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM
title_full_unstemmed A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM
title_short A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM
title_sort case of delayed hepatic injury associated with teriflunomide use as assessed for causality using the updated rucam
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217622/
https://www.ncbi.nlm.nih.gov/pubmed/35756947
http://dx.doi.org/10.1155/2022/6331923
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