A novel immune-related microRNA signature for prognosis of thymoma

Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors. Methods: Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TR...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Xiao, He, Yang, Xin, Zeng, Ying, Zhang, Zhimin, Yang, Rui, Chen, Hang, Chen, Chuan, Chen, Junxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217705/
https://www.ncbi.nlm.nih.gov/pubmed/35675033
http://dx.doi.org/10.18632/aging.204108
Descripción
Sumario:Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors. Methods: Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TREM2hi score was calculated before functional enrichment analysis on gene sets. Results: IMRS3, TREM2hi score, and CD8+ T lymphocyte abundance were significantly different among WHO classifications. WHO classification, Masaoka staging, and miR-130b-5p, miR-1307-3p, miR-425-5p, CD8, CD68, and CCL18 expression were prognostic factors for relapse-free survival and overall survival. IMRS3 upregulation polarized macrophages into M2, which rejected CD8+ T and other effector lymphocytes to promote thymoma malignant progression. Conclusions: BRRS may present a novel immune-related microRNA signature for TET prognosis.

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