A novel immune-related microRNA signature for prognosis of thymoma

Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors. Methods: Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TR...

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Autores principales: Wang, Bin, Xiao, He, Yang, Xin, Zeng, Ying, Zhang, Zhimin, Yang, Rui, Chen, Hang, Chen, Chuan, Chen, Junxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217705/
https://www.ncbi.nlm.nih.gov/pubmed/35675033
http://dx.doi.org/10.18632/aging.204108
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author Wang, Bin
Xiao, He
Yang, Xin
Zeng, Ying
Zhang, Zhimin
Yang, Rui
Chen, Hang
Chen, Chuan
Chen, Junxia
author_facet Wang, Bin
Xiao, He
Yang, Xin
Zeng, Ying
Zhang, Zhimin
Yang, Rui
Chen, Hang
Chen, Chuan
Chen, Junxia
author_sort Wang, Bin
collection PubMed
description Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors. Methods: Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TREM2hi score was calculated before functional enrichment analysis on gene sets. Results: IMRS3, TREM2hi score, and CD8+ T lymphocyte abundance were significantly different among WHO classifications. WHO classification, Masaoka staging, and miR-130b-5p, miR-1307-3p, miR-425-5p, CD8, CD68, and CCL18 expression were prognostic factors for relapse-free survival and overall survival. IMRS3 upregulation polarized macrophages into M2, which rejected CD8+ T and other effector lymphocytes to promote thymoma malignant progression. Conclusions: BRRS may present a novel immune-related microRNA signature for TET prognosis.
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spelling pubmed-92177052022-06-24 A novel immune-related microRNA signature for prognosis of thymoma Wang, Bin Xiao, He Yang, Xin Zeng, Ying Zhang, Zhimin Yang, Rui Chen, Hang Chen, Chuan Chen, Junxia Aging (Albany NY) Research Paper Introduction: Immune microenvironment and microRNAs serve as common predictors for diagnosis and prognosis of tumors. Methods: Expression of 122 genes and 126 microRNAs in thymoma was obtained from TCGA database. The proportion of tumor-infiltrating cells was calculated, and IMRS was constructed. TREM2hi score was calculated before functional enrichment analysis on gene sets. Results: IMRS3, TREM2hi score, and CD8+ T lymphocyte abundance were significantly different among WHO classifications. WHO classification, Masaoka staging, and miR-130b-5p, miR-1307-3p, miR-425-5p, CD8, CD68, and CCL18 expression were prognostic factors for relapse-free survival and overall survival. IMRS3 upregulation polarized macrophages into M2, which rejected CD8+ T and other effector lymphocytes to promote thymoma malignant progression. Conclusions: BRRS may present a novel immune-related microRNA signature for TET prognosis. Impact Journals 2022-06-07 /pmc/articles/PMC9217705/ /pubmed/35675033 http://dx.doi.org/10.18632/aging.204108 Text en Copyright: © 2022 Wang et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Bin
Xiao, He
Yang, Xin
Zeng, Ying
Zhang, Zhimin
Yang, Rui
Chen, Hang
Chen, Chuan
Chen, Junxia
A novel immune-related microRNA signature for prognosis of thymoma
title A novel immune-related microRNA signature for prognosis of thymoma
title_full A novel immune-related microRNA signature for prognosis of thymoma
title_fullStr A novel immune-related microRNA signature for prognosis of thymoma
title_full_unstemmed A novel immune-related microRNA signature for prognosis of thymoma
title_short A novel immune-related microRNA signature for prognosis of thymoma
title_sort novel immune-related microrna signature for prognosis of thymoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217705/
https://www.ncbi.nlm.nih.gov/pubmed/35675033
http://dx.doi.org/10.18632/aging.204108
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