Cohesin-mediated loop anchors confine the locations of human replication origins

DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability(1,2). At present, it is unknown how the locations of replication origins are determined in the human genome. Here we dissect the role of topologically associating domains (TADs)...

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Detalles Bibliográficos
Autores principales: Emerson, Daniel J., Zhao, Peiyao A., Cook, Ashley L., Barnett, R. Jordan, Klein, Kyle N., Saulebekova, Dalila, Ge, Chunmin, Zhou, Linda, Simandi, Zoltan, Minsk, Miriam K., Titus, Katelyn R., Wang, Weitao, Gong, Wanfeng, Zhang, Di, Yang, Liyan, Venev, Sergey V., Gibcus, Johan H., Yang, Hongbo, Sasaki, Takayo, Kanemaki, Masato T., Yue, Feng, Dekker, Job, Chen, Chun-Long, Gilbert, David M., Phillips-Cremins, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217744/
https://www.ncbi.nlm.nih.gov/pubmed/35676475
http://dx.doi.org/10.1038/s41586-022-04803-0

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