Cargando…

Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia

Severe aplastic anemia (SAA) is a life-threatening hematological disorder. The major therapies include matched sibling donor (MSD)- hematopoietic stem cell transplantation (HSCT), matched unrelated donor (MUD)-HSCT and immunosuppressive therapy (IST). However, there are many problems that can occur...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Meijie, Gui, Ruirui, Zu, Yingling, Li, Zhen, Wang, Dao, Mao, Yanna, Wang, Xianjing, Wang, Huili, Song, Yongping, Zhou, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217791/
https://www.ncbi.nlm.nih.gov/pubmed/35732877
http://dx.doi.org/10.1038/s41598-022-14665-1
_version_ 1784731733370863616
author He, Meijie
Gui, Ruirui
Zu, Yingling
Li, Zhen
Wang, Dao
Mao, Yanna
Wang, Xianjing
Wang, Huili
Song, Yongping
Zhou, Jian
author_facet He, Meijie
Gui, Ruirui
Zu, Yingling
Li, Zhen
Wang, Dao
Mao, Yanna
Wang, Xianjing
Wang, Huili
Song, Yongping
Zhou, Jian
author_sort He, Meijie
collection PubMed
description Severe aplastic anemia (SAA) is a life-threatening hematological disorder. The major therapies include matched sibling donor (MSD)- hematopoietic stem cell transplantation (HSCT), matched unrelated donor (MUD)-HSCT and immunosuppressive therapy (IST). However, there are many problems that can occur after HSCT, and graft failure (GF) is one of the most serious complications. To find an effective treatment, we analyzed 10 cases of second HSCT to treat SAA pediatric patients who suffered from GF and concluded that second haploidentical family donors HSCT is an effective treatment. Moreover, adding a small dose of busulfan or 2 ~ 3 Gy total body irradiation (TBI) in nonmyeloablative regimens (NMAs) can promote the engraftment. Although the study also showed that PBSCs, as a source of stem cells, can promote the implantation of neutrophil cells, due to small sample size, more research is still needed.
format Online
Article
Text
id pubmed-9217791
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92177912022-06-24 Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia He, Meijie Gui, Ruirui Zu, Yingling Li, Zhen Wang, Dao Mao, Yanna Wang, Xianjing Wang, Huili Song, Yongping Zhou, Jian Sci Rep Article Severe aplastic anemia (SAA) is a life-threatening hematological disorder. The major therapies include matched sibling donor (MSD)- hematopoietic stem cell transplantation (HSCT), matched unrelated donor (MUD)-HSCT and immunosuppressive therapy (IST). However, there are many problems that can occur after HSCT, and graft failure (GF) is one of the most serious complications. To find an effective treatment, we analyzed 10 cases of second HSCT to treat SAA pediatric patients who suffered from GF and concluded that second haploidentical family donors HSCT is an effective treatment. Moreover, adding a small dose of busulfan or 2 ~ 3 Gy total body irradiation (TBI) in nonmyeloablative regimens (NMAs) can promote the engraftment. Although the study also showed that PBSCs, as a source of stem cells, can promote the implantation of neutrophil cells, due to small sample size, more research is still needed. Nature Publishing Group UK 2022-06-22 /pmc/articles/PMC9217791/ /pubmed/35732877 http://dx.doi.org/10.1038/s41598-022-14665-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
He, Meijie
Gui, Ruirui
Zu, Yingling
Li, Zhen
Wang, Dao
Mao, Yanna
Wang, Xianjing
Wang, Huili
Song, Yongping
Zhou, Jian
Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
title Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
title_full Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
title_fullStr Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
title_full_unstemmed Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
title_short Successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
title_sort successful outcomes of second hematopoietic stem cell transplantation for graft failure in pediatric patients with severe aplastic anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217791/
https://www.ncbi.nlm.nih.gov/pubmed/35732877
http://dx.doi.org/10.1038/s41598-022-14665-1
work_keys_str_mv AT hemeijie successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT guiruirui successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT zuyingling successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT lizhen successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT wangdao successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT maoyanna successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT wangxianjing successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT wanghuili successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT songyongping successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia
AT zhoujian successfuloutcomesofsecondhematopoieticstemcelltransplantationforgraftfailureinpediatricpatientswithsevereaplasticanemia