Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle

Improving reproductive performance remains a major goal in dairy cattle worldwide. Service sire has been recognized as an important factor affecting herd fertility. The main objective of this study was to reveal the genetic basis of male fertility in Italian Brown Swiss dairy cattle. Dataset include...

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Autores principales: Pacheco, Hendyel A., Rossoni, Attilio, Cecchinato, Alessio, Peñagaricano, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217806/
https://www.ncbi.nlm.nih.gov/pubmed/35732705
http://dx.doi.org/10.1038/s41598-022-14889-1
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author Pacheco, Hendyel A.
Rossoni, Attilio
Cecchinato, Alessio
Peñagaricano, Francisco
author_facet Pacheco, Hendyel A.
Rossoni, Attilio
Cecchinato, Alessio
Peñagaricano, Francisco
author_sort Pacheco, Hendyel A.
collection PubMed
description Improving reproductive performance remains a major goal in dairy cattle worldwide. Service sire has been recognized as an important factor affecting herd fertility. The main objective of this study was to reveal the genetic basis of male fertility in Italian Brown Swiss dairy cattle. Dataset included 1102 Italian Brown Swiss bulls with sire conception rate records genotyped with 454k single nucleotide polymorphisms. The analysis included whole-genome scans and gene-set analyses to identify genomic regions, individual genes and genetic mechanisms affecting Brown Swiss bull fertility. One genomic region on BTA1 showed significant additive effects. This region harbors gene RABL3 which is implicated cell proliferation and motility. Two genomic regions, located on BTA6 and BTA26, showed marked non-additive effects. These regions harbor genes, such as WDR19 and ADGRA1, that are directly involved in male fertility, including sperm motility, acrosome reaction, and embryonic development. The gene-set analysis revealed functional terms related to cell adhesion, cellular signaling, cellular transport, immune system, and embryonic development. Remarkably, a gene-set analysis also including Holstein and Jersey data, revealed significant processes that are common to the three dairy breeds, including cell migration, cell–cell interaction, GTPase activity, and the immune function. Overall, this comprehensive study contributes to a better understanding of the genetic basis of male fertility in cattle. In addition, our findings may guide the development of novel genomic strategies for improving service sire fertility in Brown Swiss cattle.
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spelling pubmed-92178062022-06-24 Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle Pacheco, Hendyel A. Rossoni, Attilio Cecchinato, Alessio Peñagaricano, Francisco Sci Rep Article Improving reproductive performance remains a major goal in dairy cattle worldwide. Service sire has been recognized as an important factor affecting herd fertility. The main objective of this study was to reveal the genetic basis of male fertility in Italian Brown Swiss dairy cattle. Dataset included 1102 Italian Brown Swiss bulls with sire conception rate records genotyped with 454k single nucleotide polymorphisms. The analysis included whole-genome scans and gene-set analyses to identify genomic regions, individual genes and genetic mechanisms affecting Brown Swiss bull fertility. One genomic region on BTA1 showed significant additive effects. This region harbors gene RABL3 which is implicated cell proliferation and motility. Two genomic regions, located on BTA6 and BTA26, showed marked non-additive effects. These regions harbor genes, such as WDR19 and ADGRA1, that are directly involved in male fertility, including sperm motility, acrosome reaction, and embryonic development. The gene-set analysis revealed functional terms related to cell adhesion, cellular signaling, cellular transport, immune system, and embryonic development. Remarkably, a gene-set analysis also including Holstein and Jersey data, revealed significant processes that are common to the three dairy breeds, including cell migration, cell–cell interaction, GTPase activity, and the immune function. Overall, this comprehensive study contributes to a better understanding of the genetic basis of male fertility in cattle. In addition, our findings may guide the development of novel genomic strategies for improving service sire fertility in Brown Swiss cattle. Nature Publishing Group UK 2022-06-22 /pmc/articles/PMC9217806/ /pubmed/35732705 http://dx.doi.org/10.1038/s41598-022-14889-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Pacheco, Hendyel A.
Rossoni, Attilio
Cecchinato, Alessio
Peñagaricano, Francisco
Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
title Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
title_full Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
title_fullStr Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
title_full_unstemmed Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
title_short Deciphering the genetic basis of male fertility in Italian Brown Swiss dairy cattle
title_sort deciphering the genetic basis of male fertility in italian brown swiss dairy cattle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217806/
https://www.ncbi.nlm.nih.gov/pubmed/35732705
http://dx.doi.org/10.1038/s41598-022-14889-1
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