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Specific and sensitive GC–MS analysis of hypusine, N(ε)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
Hypusination is a unique two-step enzymatic post-translational modification of the N(ε)-amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A). We developed a specific and sensitive gas chromatography–mass spectrometry (GC–MS) method for the measurement of biological hypusine (Hyp),...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Vienna
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217869/ https://www.ncbi.nlm.nih.gov/pubmed/35243537 http://dx.doi.org/10.1007/s00726-022-03142-8 |