Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease

The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is finely regulated by endocytic events, recycling to the plasma membrane and degradation. Noteworthy, deficits in EAAT2 have bee...

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Detalles Bibliográficos
Autores principales: Iovino, Ludovica, Giusti, Veronica, Pischedda, Francesca, Giusto, Elena, Plotegher, Nicoletta, Marte, Antonella, Battisti, Ilaria, Di Iacovo, Angela, Marku, Algerta, Piccoli, Giovanni, Bandopadhyay, Rina, Perego, Carla, Bonifacino, Tiziana, Bonanno, Giambattista, Roseti, Cristina, Bossi, Elena, Arrigoni, Giorgio, Bubacco, Luigi, Greggio, Elisa, Hilfiker, Sabine, Civiero, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217889/
https://www.ncbi.nlm.nih.gov/pubmed/35596783
http://dx.doi.org/10.1007/s00401-022-02437-0

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