Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives

The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of l-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of l-arginine,...

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Detalles Bibliográficos
Autores principales: Banjarnahor, Sofna, König, Jörg, Maas, Renke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217908/
https://www.ncbi.nlm.nih.gov/pubmed/35377022
http://dx.doi.org/10.1007/s00726-022-03156-2
Descripción
Sumario:The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of l-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of l-arginine, l-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effects on CAT1-mediated transport of all tested substrates. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00726-022-03156-2.

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