Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives

The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of l-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of l-arginine,...

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Autores principales: Banjarnahor, Sofna, König, Jörg, Maas, Renke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217908/
https://www.ncbi.nlm.nih.gov/pubmed/35377022
http://dx.doi.org/10.1007/s00726-022-03156-2
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author Banjarnahor, Sofna
König, Jörg
Maas, Renke
author_facet Banjarnahor, Sofna
König, Jörg
Maas, Renke
author_sort Banjarnahor, Sofna
collection PubMed
description The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of l-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of l-arginine, l-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effects on CAT1-mediated transport of all tested substrates. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00726-022-03156-2.
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spelling pubmed-92179082022-06-24 Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives Banjarnahor, Sofna König, Jörg Maas, Renke Amino Acids Short Communication The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of l-arginine and some of its derivatives. This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 µM) on the CAT1-mediated cellular uptake of l-arginine, l-homoarginine, and asymmetric dimethylarginine (ADMA). Twenty-three (20%) of the tested substances showed weak inhibitory or stimulatory effects, but only verapamil showed consistent inhibitory effects on CAT1-mediated transport of all tested substrates. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00726-022-03156-2. Springer Vienna 2022-04-04 2022 /pmc/articles/PMC9217908/ /pubmed/35377022 http://dx.doi.org/10.1007/s00726-022-03156-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Banjarnahor, Sofna
König, Jörg
Maas, Renke
Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives
title Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives
title_full Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives
title_fullStr Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives
title_full_unstemmed Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives
title_short Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of l-arginine and arginine derivatives
title_sort screening of commonly prescribed drugs for effects on the cat1-mediated transport of l-arginine and arginine derivatives
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217908/
https://www.ncbi.nlm.nih.gov/pubmed/35377022
http://dx.doi.org/10.1007/s00726-022-03156-2
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AT maasrenke screeningofcommonlyprescribeddrugsforeffectsonthecat1mediatedtransportoflarginineandargininederivatives

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