Design, synthesis, in vitro α-glucosidase inhibition, docking, and molecular dynamics of new phthalimide-benzenesulfonamide hybrids for targeting type 2 diabetes

In the present work, a new series of 14 novel phthalimide-benzenesulfonamide derivatives 4a–n were synthesized, and their inhibitory activity against yeast α-glucosidase was screened. The obtained results indicated that most of the newly synthesized compounds showed prominent inhibitory activity aga...

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Detalles Bibliográficos
Autores principales: Askarzadeh, Mohammad, Azizian, Homa, Adib, Mehdi, Mohammadi-Khanaposhtani, Maryam, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Sajjadi-Jazi, Sayed Mahmoud, Larijani, Bagher, Hamedifar, Haleh, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217978/
https://www.ncbi.nlm.nih.gov/pubmed/35732907
http://dx.doi.org/10.1038/s41598-022-14896-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217978/
https://www.ncbi.nlm.nih.gov/pubmed/35732907
http://dx.doi.org/10.1038/s41598-022-14896-2

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