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OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation

As a main regulator of cellular responses to hypoxia, the protein stability of hypoxia-inducible factor (HIF)-1α is strictly controlled by oxygen tension dependent of PHDs-catalyzed protein hydroxylation and pVHL complex-mediated proteasomal degradation. Whether HIF-1α protein stability as well as i...

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Detalles Bibliográficos
Autores principales:	Liu, Xing, Deng, Hongyan, Tang, Jinhua, Wang, Zixuan, Zhu, Chunchun, Cai, Xiaolian, Rong, Fangjing, Chen, Xiaoyun, Sun, Xueyi, Jia, Shuke, Ouyang, Gang, Li, Wenhua, Xiao, Wuhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217984/ https://www.ncbi.nlm.nih.gov/pubmed/35732631 http://dx.doi.org/10.1038/s41419-022-05008-z

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