Communication between immune system and mycobiota impacts health and disease

Fungi are the organisms present universally in the environment from ancient times. Being regarded as an essential part of human mycobiome either as commensals or as opportunistic pathogens they hold a spectacular place in our lives. Mycobiome is growing as a field of interest, but some questions still remain lurking like how fungi exactly modulate health and disease. Most of the studies focus on the interactions of the immune system with the bacterial and viral community rather than highlighting the communication with mycobiota. Crosstalk between the immune system and mycobiota have been found to be highly necessary for maintaining homeostasis, preventing susceptibility towards diseases, inducing immune tolerance, modulating microbial communities and generating signal responses by interacting with fungal molecular patterns. We are highlighting the latest advancement regarding the relationship of innate and adaptive branches of immunity with mycobiota, their role ranging from simple commensals to opportunistic pathogens and more importantly therapies designed to overcome fungal infections in this review.