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Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke

Cerebral stroke is one of the highest-ranking causes of death and the leading cause of disability globally, particularly with an increasing incidence and prevalence in developing countries. Steadily more evidence has indicated that micro ribonucleic acids (miRNAs) have important regulatory functions...

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Autores principales: Zhang, Yuansheng, Lei, Li, Zhou, Hu, Lu, Xiaoyang, Cai, Feifei, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218061/
https://www.ncbi.nlm.nih.gov/pubmed/35755778
http://dx.doi.org/10.3389/fncel.2022.890762
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author Zhang, Yuansheng
Lei, Li
Zhou, Hu
Lu, Xiaoyang
Cai, Feifei
Li, Tao
author_facet Zhang, Yuansheng
Lei, Li
Zhou, Hu
Lu, Xiaoyang
Cai, Feifei
Li, Tao
author_sort Zhang, Yuansheng
collection PubMed
description Cerebral stroke is one of the highest-ranking causes of death and the leading cause of disability globally, particularly with an increasing incidence and prevalence in developing countries. Steadily more evidence has indicated that micro ribonucleic acids (miRNAs) have important regulatory functions in gene transcription and translation in the course of cerebral stroke. It is beyond arduous to understand the pathophysiology of cerebral stroke, due in part to the perplexity of influencing the network of the inflammatory response, brain edema, autophagy and neuronal apoptosis. The recent research shows miRNA plays a key role in regulating aquaporin 4 (AQP4), and many essential pathological processes after cerebral stroke. This article reviews the recent knowledge on how miRNA influences the inflammatory response, brain edema, infarction size, and neuronal injury after cerebral stroke. In addition, some miRNAs may serve as potential biomarkers in stroke diagnosis and therapy since the expression of some miRNAs in the blood is stable after cerebral stroke.
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spelling pubmed-92180612022-06-24 Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke Zhang, Yuansheng Lei, Li Zhou, Hu Lu, Xiaoyang Cai, Feifei Li, Tao Front Cell Neurosci Neuroscience Cerebral stroke is one of the highest-ranking causes of death and the leading cause of disability globally, particularly with an increasing incidence and prevalence in developing countries. Steadily more evidence has indicated that micro ribonucleic acids (miRNAs) have important regulatory functions in gene transcription and translation in the course of cerebral stroke. It is beyond arduous to understand the pathophysiology of cerebral stroke, due in part to the perplexity of influencing the network of the inflammatory response, brain edema, autophagy and neuronal apoptosis. The recent research shows miRNA plays a key role in regulating aquaporin 4 (AQP4), and many essential pathological processes after cerebral stroke. This article reviews the recent knowledge on how miRNA influences the inflammatory response, brain edema, infarction size, and neuronal injury after cerebral stroke. In addition, some miRNAs may serve as potential biomarkers in stroke diagnosis and therapy since the expression of some miRNAs in the blood is stable after cerebral stroke. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218061/ /pubmed/35755778 http://dx.doi.org/10.3389/fncel.2022.890762 Text en Copyright © 2022 Zhang, Lei, Zhou, Lu, Cai and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Yuansheng
Lei, Li
Zhou, Hu
Lu, Xiaoyang
Cai, Feifei
Li, Tao
Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke
title Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke
title_full Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke
title_fullStr Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke
title_full_unstemmed Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke
title_short Roles of Micro Ribonucleic Acids in Astrocytes After Cerebral Stroke
title_sort roles of micro ribonucleic acids in astrocytes after cerebral stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218061/
https://www.ncbi.nlm.nih.gov/pubmed/35755778
http://dx.doi.org/10.3389/fncel.2022.890762
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