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Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218065/ https://www.ncbi.nlm.nih.gov/pubmed/35757766 http://dx.doi.org/10.3389/fimmu.2022.905628 |
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author | Li, Tong Li, Haichao Wu, Yuqing Li, Shaojian Yuan, Guohui Xu, Pengjun |
author_facet | Li, Tong Li, Haichao Wu, Yuqing Li, Shaojian Yuan, Guohui Xu, Pengjun |
author_sort | Li, Tong |
collection | PubMed |
description | Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphids are the primary vectors of plant viruses. In this study, we identified a novel DV in Chinese Sitobion miscanthi population, provisionally named “Sitobion miscanthi densovirus” (SmDV). Taxonomically, SmDV belongs to genus Hemiambidensovirus. In S. miscanthi, SmDV is hosted in diverse cells and can be horizontally transmitted via wheat feeding. Subject to SmDV, aphids activate their intrinsic antiviral autophagy pathway. Grouped with ascorbate and aldarate metabolism, chlorophyll metabolism, p450 related drug metabolism, and retinoid metabolism, aphids form a complex immune network response to the infection of SmDV. Obviously, it works as elder aphids still alive even they contain the highest examined concentration of SmDV. This study provides a foundation for the identifications of novel DVs, and further improves the understanding of the molecular interactions between insects and DVs. |
format | Online Article Text |
id | pubmed-9218065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92180652022-06-24 Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection Li, Tong Li, Haichao Wu, Yuqing Li, Shaojian Yuan, Guohui Xu, Pengjun Front Immunol Immunology Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphids are the primary vectors of plant viruses. In this study, we identified a novel DV in Chinese Sitobion miscanthi population, provisionally named “Sitobion miscanthi densovirus” (SmDV). Taxonomically, SmDV belongs to genus Hemiambidensovirus. In S. miscanthi, SmDV is hosted in diverse cells and can be horizontally transmitted via wheat feeding. Subject to SmDV, aphids activate their intrinsic antiviral autophagy pathway. Grouped with ascorbate and aldarate metabolism, chlorophyll metabolism, p450 related drug metabolism, and retinoid metabolism, aphids form a complex immune network response to the infection of SmDV. Obviously, it works as elder aphids still alive even they contain the highest examined concentration of SmDV. This study provides a foundation for the identifications of novel DVs, and further improves the understanding of the molecular interactions between insects and DVs. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218065/ /pubmed/35757766 http://dx.doi.org/10.3389/fimmu.2022.905628 Text en Copyright © 2022 Li, Li, Wu, Li, Yuan and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Li, Tong Li, Haichao Wu, Yuqing Li, Shaojian Yuan, Guohui Xu, Pengjun Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection |
title | Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection |
title_full | Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection |
title_fullStr | Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection |
title_full_unstemmed | Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection |
title_short | Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection |
title_sort | identification of a novel densovirus in aphid, and uncovering the possible antiviral process during its infection |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218065/ https://www.ncbi.nlm.nih.gov/pubmed/35757766 http://dx.doi.org/10.3389/fimmu.2022.905628 |
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