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Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection

Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphi...

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Autores principales: Li, Tong, Li, Haichao, Wu, Yuqing, Li, Shaojian, Yuan, Guohui, Xu, Pengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218065/
https://www.ncbi.nlm.nih.gov/pubmed/35757766
http://dx.doi.org/10.3389/fimmu.2022.905628
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author Li, Tong
Li, Haichao
Wu, Yuqing
Li, Shaojian
Yuan, Guohui
Xu, Pengjun
author_facet Li, Tong
Li, Haichao
Wu, Yuqing
Li, Shaojian
Yuan, Guohui
Xu, Pengjun
author_sort Li, Tong
collection PubMed
description Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphids are the primary vectors of plant viruses. In this study, we identified a novel DV in Chinese Sitobion miscanthi population, provisionally named “Sitobion miscanthi densovirus” (SmDV). Taxonomically, SmDV belongs to genus Hemiambidensovirus. In S. miscanthi, SmDV is hosted in diverse cells and can be horizontally transmitted via wheat feeding. Subject to SmDV, aphids activate their intrinsic antiviral autophagy pathway. Grouped with ascorbate and aldarate metabolism, chlorophyll metabolism, p450 related drug metabolism, and retinoid metabolism, aphids form a complex immune network response to the infection of SmDV. Obviously, it works as elder aphids still alive even they contain the highest examined concentration of SmDV. This study provides a foundation for the identifications of novel DVs, and further improves the understanding of the molecular interactions between insects and DVs.
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spelling pubmed-92180652022-06-24 Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection Li, Tong Li, Haichao Wu, Yuqing Li, Shaojian Yuan, Guohui Xu, Pengjun Front Immunol Immunology Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphids are the primary vectors of plant viruses. In this study, we identified a novel DV in Chinese Sitobion miscanthi population, provisionally named “Sitobion miscanthi densovirus” (SmDV). Taxonomically, SmDV belongs to genus Hemiambidensovirus. In S. miscanthi, SmDV is hosted in diverse cells and can be horizontally transmitted via wheat feeding. Subject to SmDV, aphids activate their intrinsic antiviral autophagy pathway. Grouped with ascorbate and aldarate metabolism, chlorophyll metabolism, p450 related drug metabolism, and retinoid metabolism, aphids form a complex immune network response to the infection of SmDV. Obviously, it works as elder aphids still alive even they contain the highest examined concentration of SmDV. This study provides a foundation for the identifications of novel DVs, and further improves the understanding of the molecular interactions between insects and DVs. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218065/ /pubmed/35757766 http://dx.doi.org/10.3389/fimmu.2022.905628 Text en Copyright © 2022 Li, Li, Wu, Li, Yuan and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Tong
Li, Haichao
Wu, Yuqing
Li, Shaojian
Yuan, Guohui
Xu, Pengjun
Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
title Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
title_full Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
title_fullStr Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
title_full_unstemmed Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
title_short Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection
title_sort identification of a novel densovirus in aphid, and uncovering the possible antiviral process during its infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218065/
https://www.ncbi.nlm.nih.gov/pubmed/35757766
http://dx.doi.org/10.3389/fimmu.2022.905628
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